Document Detail


Identification of features of metaplastic cells in sputum for the detection of squamous-cell carcinoma of the lung.
MedLine Citation:
PMID:  2721359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Digitized images of 1,556 squamous metaplastic cells from the sputum of 15 patients with confirmed squamous-cell carcinoma of the lung and 13 subjects without apparent neoplasia were analyzed to determine if features existed within these relatively normal cells that could be used to differentiate between the two populations. Results indicate that such marker features do exist. A cross-validation study using an additional 465 cells confirmed the conclusion that squamous metaplastic cells from patients with squamous-cell carcinoma of the lung do differ from those of subjects without cancer. While such marker features alone are not reliable enough to assist pathologists in the diagnosis of squamous-cell carcinoma of the lung, they might, in sufficient numbers, be used to identify patients for whom follow-up testing would be advised.
Authors:
P R Swank; S D Greenberg; N R Hunter; H J Spjut; R Estrada; E B Trahan; J Montalvo
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Diagnostic cytopathology     Volume:  5     ISSN:  8755-1039     ISO Abbreviation:  Diagn. Cytopathol.     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-28     Completed Date:  1989-06-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8506895     Medline TA:  Diagn Cytopathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Affiliation:
Educational Psychology Department, University of Houston, TX.
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MeSH Terms
Descriptor/Qualifier:
Carcinoma, Squamous Cell / pathology*
Humans
Lung Neoplasms / pathology*
Metaplasia
Precancerous Conditions / pathology
Sputum / cytology*
Tumor Markers, Biological / analysis*
Grant Support
ID/Acronym/Agency:
CA-27313/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Markers, Biological

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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