Document Detail


Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family.
MedLine Citation:
PMID:  23203913     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Sphingolipids represent a major class of lipids which both serve as structural components of membranes and as bioactive molecules involved in lipid signaling. Ceramide synthases (cers) reside in the center of sphingolipid metabolism by producing ceramide through de novo synthesis or degradative pathways. While the six mammalian cers family members have been extensively studied in cell culture and in adult tissues, a systematic analysis of cers expression and function during embryogenesis is still lacking. RESULTS: Using bioinformatic and phylogenetic analysis we identified nine highly conserved homologs of the vertebrate cers gene family in the zebrafish genome. A systematic expression analysis throughout five developmental stages indicates that whereas until 48 hpf most zebrafish cers homologs are expressed in distinct patterns, e.g. in the intermediate cell mass and the pronephric duct, they show a highly overlapping expression during later stages of embryonic development, most prominently in the developing brain. CONCLUSIONS: In this study the expression of the cers gene homologs is comprehensively analyzed for the first time during vertebrate embryogenesis. Our data indicate that each embryonic tissue has a unique profile of cers expression during zebrafish embryogenesis suggesting tissue-specific profiles of ceramides and their derivatives.
Authors:
Mirco Brondolin; Susanne Berger; Michael Reinke; Hideomi Tanaka; Toshio Ohshima; Bernhard Fuß; Michael Hoch
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  -     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
University of Bonn, LIMES Institute, Bonn, Germany.
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