| Identification of distant metastases with positron-emission tomography-computed tomography in patients with previously untreated head and neck cancer. | |
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MedLine Citation:
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PMID: 18197136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To investigate the utility of positron-emission tomography-computed tomography (PET-CT) in identifying distant metastatic disease in patients with previously untreated head and neck squamous cell cancer (HNSCC) prior to definitive treatment. MATERIALS AND METHODS: Retrospective analysis of 27 consecutive patients with previously untreated HNSCC who underwent PET-CT imaging in addition to chest radiography (CXR) as part of their metastatic workup. RESULTS: The majority of patients (89%) had TNM stage III or IV disease. PET-CT was suspicious for pulmonary malignancy in four (15%) patients and indeterminate in one (4%) patient. CXR was suspicious for pulmonary malignancy in two (7%) patients. Pulmonary metastases or a new lung primary was present in 3 (11%) patients: 3 of 4 (75%) patients with positive PET-CT scans and 0 of 23 (0%) patients with negative or indeterminate PET-CT scans compared with 2 of 2 (100%) patients with positive CXR and 1 of 25 (4%) patients with negative CXR. The sensitivity and specificity of PET-CT in predicting pulmonary malignancy was 100% and 96%, respectively, with a positive predictive value of 75% and a negative predictive value of 100%. The sensitivity and specificity of CXR in predicting pulmonary malignancy was 67% and 100%, respectively, with a positive predictive value of 100% and a negative predictive value of 96%. Including nonpulmonary sites, the overall incidence of distant metastatic disease was 19% (5/27) with 11% (3/27) unsuspected prior to PET-CT. CONCLUSIONS: PET-CT improves detection of metastatic disease in the high-risk patient and should be performed as part of the routine pretreatment evaluation of patients with advanced stage HNSCC. |
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Authors:
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Christine G Gourin; Tammara L Watts; Hadyn T Williams; Vijay S Patel; Paul A Bilodeau; Teresa A Coleman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Laryngoscope Volume: 118 ISSN: 0023-852X ISO Abbreviation: Laryngoscope Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-03-31 Completed Date: 2008-06-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8607378 Medline TA: Laryngoscope Country: United States |
Other Details:
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Languages: eng Pagination: 671-5 Citation Subset: IM |
Affiliation:
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Department of Otolaryngology-Head and Neck Surgery, Medical College of Georgia, Augusta, Georgia, USA. cgourin1@jhmi.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma, Squamous Cell
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diagnosis,
secondary* Contrast Media Female Fluorodeoxyglucose F18 / diagnostic use Follow-Up Studies Head and Neck Neoplasms / pathology* Humans Laryngeal Neoplasms / pathology Lung Neoplasms / diagnosis, secondary* Male Middle Aged Mouth Neoplasms / pathology Neoplasm Staging Oropharyngeal Neoplasms / pathology Positron-Emission Tomography / methods* Predictive Value of Tests Radiography, Thoracic Radiopharmaceuticals / diagnostic use Retrospective Studies Sensitivity and Specificity Tomography, Spiral Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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