| Identification of dihydropyridines that reduce cellular tau levels. | |
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MedLine Citation:
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PMID: 21082080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary structure-activity relationships. |
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Authors:
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Christopher G Evans; Umesh K Jinwal; Leah N Makley; Chad A Dickey; Jason E Gestwicki |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-16 |
Journal Detail:
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Title: Chemical communications (Cambridge, England) Volume: 47 ISSN: 1364-548X ISO Abbreviation: Chem. Commun. (Camb.) Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-08 Completed Date: 2011-03-22 Revised Date: 2013-04-12 |
Medline Journal Info:
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Nlm Unique ID: 9610838 Medline TA: Chem Commun (Camb) Country: England |
Other Details:
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Languages: eng Pagination: 529-31 Citation Subset: IM |
Affiliation:
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Department of Pathology and the Life Sciences Institute, University of Michigan, 210 Washtenaw Ave., Ann Arbor, MI 48109, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cyclization Dihydropyridines / chemical synthesis, chemistry*, pharmacology Humans Molecular Structure Oxidation-Reduction Stereoisomerism Structure-Activity Relationship Tumor Cells, Cultured tau Proteins / antagonists & inhibitors, biosynthesis* |
| Grant Support | |
ID/Acronym/Agency:
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AG031291/AG/NIA NIH HHS; GM008353/GM/NIGMS NIH HHS; NS059690/NS/NINDS NIH HHS; R01 NS059690/NS/NINDS NIH HHS; R01 NS059690-04/NS/NINDS NIH HHS; R01 NS059690-05/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Dihydropyridines; 0/tau Proteins; 7M8K3P6I89/1,4-dihydropyridine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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