Document Detail


Identification of di(beta-phenylisopropyl)amine as the main ingredient in illicit amphetamine tablets.
MedLine Citation:
PMID:  12645186     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The identification of di(beta-phenylisopropyl)amine found as the main ingredient in several sets of amphetamine tablets sold on the illicit market in Rome, Italy, during 1999-2000 is described. The identification was achieved by examining the ultraviolet and nuclear magnetic resonance spectral properties as well as the chromatographic, gas chromatographic, and mass spectrometric data. The molecular structure of the ingredient showed a close analogy to the amphetamine and could very likely produce similar pharmacological activity. A preliminary test on the metabolic pathway of di(beta-phenylisopropyl)amine performed on rats, suggests its biotransformation to amphetamine.
Authors:
Valeria Ottaviano; Carmelo Furnari; Felice Rosati
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annali dell'Istituto superiore di sanità     Volume:  38     ISSN:  0021-2571     ISO Abbreviation:  Ann. Ist. Super. Sanita     Publication Date:  2002  
Date Detail:
Created Date:  2003-03-20     Completed Date:  2003-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7502520     Medline TA:  Ann Ist Super Sanita     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  331-5     Citation Subset:  IM    
Affiliation:
Dipartimento di Sanità Pubblica, Laboratorio di Tossicologia Forense, Università degli Studi Tor Vergata, Via Montpellier 1, 00133 Roma.
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MeSH Terms
Descriptor/Qualifier:
Amphetamines / chemistry*,  isolation & purification*
Street Drugs / chemistry*
Tablets / chemistry
Chemical
Reg. No./Substance:
0/Amphetamines; 0/Street Drugs; 0/Tablets; 0/di(beta-phenylisopropyl)amine

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