| Identification of crystals in kidneys of AIDS patients treated with foscarnet. | |
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MedLine Citation:
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PMID: 9740154 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Three acquired immune deficiency syndrome patients given foscarnet to treat cytomegalovirus retinitis developed renal failure with crystal deposits within the renal glomeruli. We identified these crystals as a mixture of sodium salt, calcium salt, and a mixed salt containing both sodium and calcium ions. This composition has not been previously reported. Foscarnet can complex available ionized calcium and secondarily precipitate in glomeruli. The percentage of complexing depends on calcium concentration in serum and the poor calcium salt solubility. |
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Authors:
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L Maurice-Estepa; M Daudon; C Katlama; C Jouanneau; V Sazdovitch; B Lacour; H Beaufils |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 32 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-09-28 Completed Date: 1998-09-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 392-400 Citation Subset: IM; X |
Affiliation:
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Service de Biochimie A and INSERM U 423, Hôpital Necker-Enfants Malades, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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AIDS-Related Opportunistic Infections
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drug therapy*,
pathology Acquired Immunodeficiency Syndrome / drug therapy*, pathology Adult Antiviral Agents / adverse effects*, therapeutic use Crystallization Cytomegalovirus Retinitis / drug therapy*, pathology Fatal Outcome Foscarnet / adverse effects*, therapeutic use Humans Kidney Failure / chemically induced*, pathology Kidney Glomerulus / drug effects, pathology Male Microscopy, Confocal Middle Aged Spectroscopy, Fourier Transform Infrared |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 4428-95-9/Foscarnet |
| Comments/Corrections | |
Comment In:
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Am J Kidney Dis. 1998 Sep;32(3):519-20
[PMID:
9740173
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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