| Identification of components of Prunus africana extract that inhibit lipid peroxidation. | |
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MedLine Citation:
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PMID: 11962548 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extractive and chromatographic separations were performed on V-1326, a chloroform extract from the bark of Prunus africana (also referred to as Pygeum africanum), which is used to treat the symptoms associated with benign prostate hyperplasia (BPH). The relative amounts of eleven identified constituents in crude V-1326 and in separated fractions were determined using gas chromatographic analysis. The ability of V-1326 and its separated fractions to inhibit ferrous ion-induced stimulation of lipid peroxidation in microsomal preparations from rabbit livers was evaluated. The extract, V-1326, and fractions containing high levels of myristic acid potently inhibited lipid peroxidation. |
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Authors:
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M A Hass; D M Nowak; E Leonova; R M Levin; P A Longhurst |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Phytomedicine : international journal of phytotherapy and phytopharmacology Volume: 6 ISSN: 0944-7113 ISO Abbreviation: Phytomedicine Publication Date: 1999 Nov |
Date Detail:
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Created Date: 2002-04-18 Completed Date: 2002-05-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9438794 Medline TA: Phytomedicine Country: Germany |
Other Details:
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Languages: eng Pagination: 379-88 Citation Subset: IM |
Affiliation:
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Division of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, NY 12208, USA. hassm@panther.acp.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Assay Chromatography, Gas Inhibitory Concentration 50 Lipid Peroxidation / drug effects* Myristic Acid Plant Extracts / isolation & purification*, pharmacology* Prunus / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Plant Extracts; 544-63-8/Myristic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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