Document Detail


Identification of components of Prunus africana extract that inhibit lipid peroxidation.
MedLine Citation:
PMID:  11962548     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extractive and chromatographic separations were performed on V-1326, a chloroform extract from the bark of Prunus africana (also referred to as Pygeum africanum), which is used to treat the symptoms associated with benign prostate hyperplasia (BPH). The relative amounts of eleven identified constituents in crude V-1326 and in separated fractions were determined using gas chromatographic analysis. The ability of V-1326 and its separated fractions to inhibit ferrous ion-induced stimulation of lipid peroxidation in microsomal preparations from rabbit livers was evaluated. The extract, V-1326, and fractions containing high levels of myristic acid potently inhibited lipid peroxidation.
Authors:
M A Hass; D M Nowak; E Leonova; R M Levin; P A Longhurst
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytomedicine : international journal of phytotherapy and phytopharmacology     Volume:  6     ISSN:  0944-7113     ISO Abbreviation:  Phytomedicine     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2002-04-18     Completed Date:  2002-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9438794     Medline TA:  Phytomedicine     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  379-88     Citation Subset:  IM    
Affiliation:
Division of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, NY 12208, USA. hassm@panther.acp.edu
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MeSH Terms
Descriptor/Qualifier:
Biological Assay
Chromatography, Gas
Inhibitory Concentration 50
Lipid Peroxidation / drug effects*
Myristic Acid
Plant Extracts / isolation & purification*,  pharmacology*
Prunus / chemistry*
Chemical
Reg. No./Substance:
0/Plant Extracts; 544-63-8/Myristic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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