Document Detail

Identification of a circuit-based endophenotype for familial depression.
MedLine Citation:
PMID:  22516664     Owner:  NLM     Status:  MEDLINE    
Frontal and parietal lesions may cause depression, and cortical thinning of the right frontal and parietal lobes has been shown to be a marker of risk for familial major depression. We studied biological offspring within a three-generation cohort, in which risk was defined by the depression status of the first generation, to identify regional volume differences associated with risk for depression throughout the cerebrum. We found reduced frontal and parietal white matter volumes in the high-risk group, including in persons without any personal history of depression, suggesting that hypoplasia of frontal and parietal white matter is an endophenotype for familial depression. In addition, white matter volumes in these regions correlated with current severity of symptoms of depression, inattention, and impulsivity. White matter volumes also correlated strongly with the degree of thinning in the right parietal cortex. These findings support a model of pathogenesis in which hypoplasia within a neural network for attention and emotional processing predisposes to depression.
Marc J Dubin; Marc Dubin; Myrna M Weissman; Myrna Weissman; Dongrong Xu; Ravi Bansal; Xuejun Hao; Jun Liu; Virginia Warner; Bradley S Peterson; Bradley Peterson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-18
Journal Detail:
Title:  Psychiatry research     Volume:  201     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-07-24     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  175-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Brain / physiopathology*
Brain Mapping
Depression / pathology*,  physiopathology*
Family Health*
Image Processing, Computer-Assisted
Longitudinal Studies
Magnetic Resonance Imaging
Middle Aged
Nerve Fibers, Myelinated / pathology
Psychiatric Status Rating Scales
Retrospective Studies
Statistics as Topic
Young Adult
Grant Support
K02-74677//PHS HHS; MH36197/MH/NIMH NIH HHS; R01 MH036197/MH/NIMH NIH HHS; R01 MH036197-27/MH/NIMH NIH HHS; T32 MH016434/MH/NIMH NIH HHS; T32 MH016434-31/MH/NIMH NIH HHS; T32-16434//PHS HHS
Erratum In:
Psychiatry Res. 2013 Jan 30;211(1):92
Note: Dubin, Marc [corrected to Dubin, Marc J]; Weissman, Myrna [corrected to Weissman, Myrna M]; Peterson, Bradley [corrected to Peterson, Bradley S]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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