Document Detail


Identification and characterization of two polymorphic Ya5 Alu repeats.
MedLine Citation:
PMID:  9360633     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Two new polymorphic Alu elements (HS2.25 and HS4.14) belonging to the young (Ya5/8) subfamily of human-specific Alu repeats have been identified. DNA sequence analysis of both Alu repeats revealed that each Alu repeat had a long 3'-oligo-dA-rich tail (41 and 52 nucleotides in length) and a low level of random mutations. HS2.25 and HS4.14 were flanked by short precise direct repeats of 8 and 14 nucleotides in length, respectively. HS2.25 was located on human chromosome 13, and HS4.14 on chromosome 1. Both Alu elements were absent from the orthologous positions within the genomes of non-human primates, and were highly polymorphic in a survey of twelve geographically diverse human groups.
Authors:
S S Arcot; M M DeAngelis; S T Sherry; A W Adamson; J E Lamerdin; P L Deininger; A V Carrano; M A Batzer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mutation research     Volume:  382     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-12-01     Completed Date:  1997-12-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  5-11     Citation Subset:  IM    
Affiliation:
Human Genome Center, Lawrence Livermore National Laboratory, Livermore, CA 94551, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Chromosome Mapping
Chromosomes, Human, Pair 1 / genetics
Chromosomes, Human, Pair 13 / genetics
Gene Frequency
Genetic Variation / genetics
Haplorhini
Heterozygote
Humans
Molecular Sequence Data
Phylogeny
Polymorphism, Genetic*
Repetitive Sequences, Nucleic Acid / genetics*
Sequence Analysis, DNA
Grant Support
ID/Acronym/Agency:
HG 00770/HG/NHGRI NIH HHS

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