Document Detail

Identification and characterization of two mtf-1 genes in common carp.
MedLine Citation:
PMID:  18602497     Owner:  NLM     Status:  MEDLINE    
The Metal-responsive Transcription Factor (MTF-1) serves as an essential regulator of Zn(2+) homeostasis via the activation of metallothionein gene expression. Only a single mtf-1 gene has been identified in any organism investigated previously. We report here the first evidence of the existence of two genes encoding MTF-1 proteins (mtf-1.1 and mtf-1.2). The expression patterns were followed in the liver, kidney, muscle, brain and heart by means of Northern hybridization and reverse transcription coupled polymerase chain reactions (RT-PCR). mtf-1.1 mRNA was detected in all tissues examined, with the highest level in the brain, and the lowest in the kidney and the liver. mtf-1.2 expression was detected exclusively in the brain. Cold shock and Cd(2+) exposure influence the gene expression at the transcriptional level, in a stress-specific manner.
Agnes Ferencz; Edit Hermesz
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Publication Detail:
Type:  Journal Article     Date:  2008-06-14
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  148     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-18     Completed Date:  2008-10-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  238-43     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, Faculty of Science, University of Szeged, P.O. Box 533, H-6701 Szeged, Hungary.
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MeSH Terms
Amino Acid Sequence
Brain / metabolism
Cadmium / toxicity
Carps / genetics*
DNA-Binding Proteins / genetics*
Genes / genetics*
Hypothermia / metabolism
Molecular Sequence Data
Sequence Alignment
Transcription Factors / genetics*
Zebrafish / genetics
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Transcription Factors; 0/transcription factor MTF-1; 7440-43-9/Cadmium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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