| Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation. | |
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MedLine Citation:
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PMID: 19109136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CD160 has been initially identified as a GPI-anchored MHC-class I activating receptor mainly expressed on peripheral blood NK cells. Herein, we report the identification of three additional CD160-related mRNAs generated through alternative splicings of the CD160 gene, among which one encoded a putative CD160 transmembrane isoform (CD160-TM). We first establish that CD160-TM surface expression is highly restricted to NK cells and is activation-dependent. Additionally, we provide evidence that CD160-TM represents a novel activating receptor, as assessed by the increased CD107a NK cell surface mobilization observed upon its engagement. Finally, we demonstrate that the CD160-TM cytoplasmic tail is by itself sufficient to mediate the recruitment of Erk1/2 signaling pathway, and that the initiation of this activation process is dependent on the Src-family kinase p56(lck). The identification of CD160-TM therefore provides new possibilities regarding the role of CD160 isoforms in the regulation of NK cell functions. |
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Authors:
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Jérôme Giustiniani; Armand Bensussan; Anne Marie-Cardine |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 182 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-12-25 Completed Date: 2009-02-13 Revised Date: 2013-03-12 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 63-71 Citation Subset: AIM; IM |
Affiliation:
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Institeut National de la Santé et de la Recherche Médicale Unite 841, Department of Immunology, Université Paris 12, Faculté de Médecine de Créteil, Créteil, France. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/EU016100; EU016101 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Antigens, CD / biosynthesis, genetics, isolation & purification*, physiology Base Sequence CD8-Positive T-Lymphocytes / immunology Cell Line Cell Line, Tumor Clone Cells G0 Phase / genetics, immunology GPI-Linked Proteins Gene Expression Regulation / immunology* Humans Jurkat Cells Killer Cells, Natural / cytology, immunology*, metabolism* Lymphocyte Activation / genetics, immunology* Membrane Proteins / biosynthesis, genetics, isolation & purification*, physiology* Molecular Sequence Data Protein Isoforms / biosynthesis, genetics, isolation & purification, physiology RNA, Messenger / isolation & purification Receptors, Immunologic / biosynthesis, genetics, isolation & purification*, physiology |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CD160 protein, human; 0/GPI-Linked Proteins; 0/Membrane Proteins; 0/Protein Isoforms; 0/RNA, Messenger; 0/Receptors, Immunologic |
| Comments/Corrections | |
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