| Identification and characterization of super-responders after cardiac resynchronization therapy. | |
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MedLine Citation:
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PMID: 20403487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac resynchronization therapy (CRT) has been shown to induce a spectacular effect on left ventricular (LV) function in certain patients. Our aim was to analyze and characterize the super-responders (SRs) to CRT using echocardiography in 186 patients with a conventional indication according to the European Society Cardiology guidelines. The investigation took place before and 6 months after implantation. CRT-SRs were defined by an improvement of the New York Heart Association functional class and LV ejection fraction to > or = 50% in absolute values associated with a relative LV end-systolic volume reduction of > or = 15%. Of the 186 patients, 18 (9.7%) were identified as CRT-SRs and had a significantly lower prevalence of ischemic etiology (11%), lower LV dimensions, lower left atrial volume, and greater global longitudinal strain at baseline. Receiver operating characteristics curves identified global longitudinal strain as the strongest parameter for predicting CRT-SRs, with a cutoff value of -12% (area under the curve 0.87, sensitivity 71%, and specificity 85%, p <0.01). In conclusion, in the present retrospective study, only a left atrial volume <55 ml and global longitudinal strain < or = -12% were independent predictors of CRT-SRs. |
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Authors:
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Patricia Reant; Amira Zaroui; Erwan Donal; Aude Mignot; Pierre Bordachar; Antoine Deplagne; Aude Solnon; Philippe Ritter; Jean-Claude Daubert; Jacques Clementy; Christophe Leclercq; Raymond Roudaut; Gilbert Habib; Stephane Lafitte |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: The American journal of cardiology Volume: 105 ISSN: 1879-1913 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-20 Completed Date: 2010-06-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1327-35 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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CHU de Bordeaux, Bordeaux, France. patricia.reant@chu-bordeaux.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Volume Defibrillators, Implantable Echocardiography, Doppler Electric Countershock* Female Follow-Up Studies Heart Failure / physiopathology, therapy*, ultrasonography Humans Male Middle Aged ROC Curve Retrospective Studies Treatment Outcome Ventricular Function / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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