Document Detail

Identification and characterization of satellite III subfamilies to the acrocentric chromosomes.
MedLine Citation:
PMID:  11330397     Owner:  NLM     Status:  MEDLINE    
The centromeres and the short arms of the five pairs of acrocentric chromosomes in humans are composed of tandemly ordered repetitive DNA. Previous studies have suggested that the exchanges between acrocentric chromosomes have resulted in concerted evolution of different DNA sequences in their short arms. The acrocentric chromosomes are clinically relevant since they are involved in Robertsonian translocation formation and non-disjunction resulting in aneuploidy. Here we have identified seven new satellite III repetitive DNA subfamilies, determined their nucleotide sequences and established their chromosomal distributions on the short arms of the acrocentric chromosomes. Knowledge of these related sequences may help to elucidate the molecular basis of Robertsonian translocation formation.
R Bandyopadhyay; C McQuillan; S L Page; K H Choo; L G Shaffer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology     Volume:  9     ISSN:  0967-3849     ISO Abbreviation:  Chromosome Res.     Publication Date:  2001  
Date Detail:
Created Date:  2001-05-01     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9313452     Medline TA:  Chromosome Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  223-33     Citation Subset:  IM    
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF208194;  AF218191;  AF218192;  AF298074;  AF298075;  AF298193
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MeSH Terms
Base Sequence
Chromosome Aberrations / etiology*
Chromosome Disorders
Chromosome Segregation
Chromosomes, Human / genetics*,  ultrastructure
DNA, Satellite / classification*
Evolution, Molecular
Molecular Sequence Data
Sequence Homology, Nucleic Acid
Translocation, Genetic
Reg. No./Substance:
0/DNA, Satellite

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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