| Identification and characterization of autocrine-motility-factor-like activity in oral squamous-cell-carcinoma cells. | |
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MedLine Citation:
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PMID: 7989119 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A human oral squamous-cell-carcinoma cell line, HOC313, was found to produce a factor which stimulates cell motility in an autocrine manner. The motility factor of HOC313 cells also promoted the locomotory activity of B16 murine melanoma cells reported to be sensitive to autocrine motility factor (AMF). HOC313 cells were found to express a large amount of AMF-receptor mRNA. In addition, the cell motility activity of HOC313 cells was completely blocked by pertussis toxin, a known inhibitor of AMF activity, suggesting that the motility factor of HOC313 cells may be AMF or a closely related factor. Immunocytochemical analysis has revealed that the AMF-like factor of HOC313 cells diminishes the cell-surface expression of adhesive molecule E-cadherin. These results suggest that down-regulation of E-cadherin may be involved in the cell-motility activity induced by the AMF-like factor of HOC313 cells. |
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Authors:
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A Ishisaki; S Oida; F Momose; T Amagasa; K Rikimaru; H Ichijo; S Sasaki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 59 ISSN: 0020-7136 ISO Abbreviation: Int. J. Cancer Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-01-12 Completed Date: 1995-01-12 Revised Date: 2007-07-24 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 783-8 Citation Subset: IM |
Affiliation:
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Department of Oral and Maxillofacial Surgery, Tokyo Medical and Dental University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autocrine Motility Factor / analysis*, antagonists & inhibitors, pharmacology Cadherins / analysis Carcinoma, Squamous Cell / chemistry*, pathology Cell Movement / drug effects Chromatography, Gel Culture Media, Conditioned Humans Melanoma, Experimental / pathology Mice Mouth Neoplasms / chemistry*, pathology Pertussis Toxin RNA, Messenger / analysis RNA, Neoplasm / analysis Tumor Cells, Cultured Virulence Factors, Bordetella / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Autocrine Motility Factor; 0/Cadherins; 0/Culture Media, Conditioned; 0/RNA, Messenger; 0/RNA, Neoplasm; 0/Virulence Factors, Bordetella; EC 2.4.2.31/Pertussis Toxin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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