Document Detail


Identification and characterization of autoantibody-producing B220(low) B (B-1) cells appearing in malarial infection.
MedLine Citation:
PMID:  20231018     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mice with malaria showed unique immunological responses, including the expansion of NK1.1(-)TCR(int) cells (extrathymic T cells). Since TCR(int) cells with autoreactivity and autoantibody-producing B cells (B-1 cells) are often simultaneously activated under autoimmune conditions, it was examined whether B-1 cells were activated in the course of malarial infection. From days 14 after infection, B220(low) B-1 cells appeared in the liver and spleen. The number of B220(low) B cells was highest at day 14, but the ratio was highest at days 28-35. In parallel with the appearance of B220(low) cells, autoantibodies against HEp-2 cells and double-stranded DNA were detected in sera. These B220(low) cells had phenotypes of CD44(high), CD23(-) and CD62L(-). In sharp contrast, conventional B220(high) B cells (B-2 cells) were CD44(low), CD23(+) and CD62L(+). These results suggested that malaria immune responses were not mediated by conventional T and B cells but resembled the responses during autoimmune diseases.
Authors:
Yasuhiro Kanda; Hiroki Kawamura; Hiroaki Matsumoto; Takahiro Kobayashi; Toshihiko Kawamura; Toru Abo
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Publication Detail:
Type:  Journal Article     Date:  2010-02-25
Journal Detail:
Title:  Cellular immunology     Volume:  263     ISSN:  1090-2163     ISO Abbreviation:  Cell. Immunol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-08-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1246405     Medline TA:  Cell Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Immunology, Niigata University School of Medicine, Niigata 951-8510, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Antinuclear / metabolism*
Antigens, CD / biosynthesis
Antigens, CD45 / biosynthesis
B-Lymphocyte Subsets / immunology,  metabolism*,  parasitology,  pathology
B-Lymphocytes / immunology,  metabolism*,  parasitology,  pathology
Hep G2 Cells
Humans
Liver / metabolism,  pathology
Malaria / immunology*,  pathology,  physiopathology
Mice
Mice, Inbred C57BL
Parasitemia
Plasmodium / immunology*,  pathogenicity
Spleen / pathology
Transaminases / metabolism
Chemical
Reg. No./Substance:
0/Antibodies, Antinuclear; 0/Antigens, CD; EC 2.6.1.-/Transaminases; EC 3.1.3.48/Antigens, CD45

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