Document Detail

Identification and characterisation of osteoarthritis patients with inflammation derived tissue turnover.
MedLine Citation:
PMID:  24216059     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Osteoarthritis (OA) is a degenerative disease with a subset of patients experiencing joint inflammation, but C-reactive protein (CRP) has shown limited use in OA as a diagnostic marker. The aim was to identify subpopulations of patients with high or low levels of acute (hsCRP) and/or matrix metalloproteinase (MMP) derived inflammation (CRPM) and investigate the subpopulations' association with biomarkers of collagen degradation and Kellgren-Lawrence score (KL).
METHODS: hsCRP, CRPM and MMP-degraded type I, II and III collagen (C1M, C2M and C3M) were quantified by ELISA in serum of 342 patients with symptomatic knee OA of which 60 underwent total knee replacement (TKR). KL was obtained. Patients were divided into quartiles by hsCRP and CRPM levels, where Q1 and Q4 were low or high in both. The biomarker levels of healthy adults provided in the ELISA kits were used as reference level.
RESULTS: hsCRP was elevated in TKR (5.9(3.6-8.2 95% CI)μg/mL) compared to reference level (3μg/mL), while CRPM was highly elevated with OA independent of KL (10-14ng/mL) compared to reference level (5ng/mL). Q4 had higher KL than Q1 (P<0.001), Q2 (P=0.017) and Q3 (P<0.001). C1M, C2M and C3M were lowest in Q1. C1M was elevated in Q3 compared to Q2 (P<0.001), whereas C3M was lower (P=0.019).
CONCLUSION: A bigger proportion of patients were elevated in CRPM compared to hsCRP, indicating MMP-derived inflammation as a component of OA. Moreover, the levels of MMP-degraded collagens differed between the subgroups segregated by inflammation, indicating distinctively different subpopulation selected by inflammation.
A S Siebuhr; Kristian Kjær Petersen; Lars Arendt-Nielsen; Line L Egsgaard; Thomas Eskehave; Claus Christiansen; Ole Simonsen; Hans Christian Hoeck; Morten A Karsdal; Anne C Bay-Jensen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-8
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  -     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.
Rheumatology, Biomarkers and Research, Nordic Bioscience, Herlev, Denmark. Electronic address:
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