Document Detail


Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis. Application to cases from industrial rubber products.
MedLine Citation:
PMID:  8156758     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
3 cases of allergic contact dermatitis from industrial rubber products were investigated using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC), GC-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC). Our studies revealed N-isopropyl-N'-phenyl-p-phenylenediamine (IPPD), a typical rubber allergen, as a causative chemical in a case from a brand of heavy-duty rubber gloves and a case from a black rubber ring for car manufacture, and zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamate (DTC)-type accelerator, as a causative chemical in a case from a brand of rubber work gloves: both IPPD and ZEPC, which showed positive patch test reactions, were confirmed in the extracts of the causative rubber products by GC, GC-MS and/or HPLC.
Authors:
M A Kaniwa; K Isama; A Nakamura; H Kantoh; M Itoh; M Ichikawa; R Hayakawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  30     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-05-19     Completed Date:  1994-05-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  20-5     Citation Subset:  IM    
Affiliation:
National Institute of Hygienic Sciences, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antioxidants / adverse effects,  analysis
Automobiles
Dermatitis, Allergic Contact / diagnosis*,  etiology*
Dermatitis, Occupational / diagnosis*,  etiology*
Dimethylamines / adverse effects,  analysis
Ditiocarb / adverse effects,  analogs & derivatives,  analysis
Female
Gloves, Protective
Humans
Male
Middle Aged
Patch Tests* / methods
Phenylenediamines / adverse effects,  analysis
Rubber / adverse effects*,  analysis*
Ziram / adverse effects,  analysis
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Dimethylamines; 0/Phenylenediamines; 101-54-2/4-aminodiphenylamine; 101-72-4/N-isopropyl-N-phenyl-4-phenylenediamine; 124-40-3/dimethylamine; 137-30-4/Ziram; 14634-93-6/zinc ethylphenyldithiocarbamate; 147-84-2/Ditiocarb; 9006-04-6/Rubber

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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