Document Detail

Identification of causative chemicals of allergic contact dermatitis using a combination of patch testing in patients and chemical analysis. Application to cases from rubber gloves.
MedLine Citation:
PMID:  7750271     Owner:  NLM     Status:  MEDLINE    
5 cases of allergic contact dermatitis from rubber gloves were investigated by our recommended procedures using a combination of patch testing in patients and chemical analysis of causative rubber products by gas chromatography (GC) and high-performance liquid chromatography (HPLC). We previously confirmed that zinc ethylphenyldithiocarbamate (ZEPC), a dithiocarbamae-type accelerator (DTC), was causative in a case of allergic contact dermatitis from rubber work gloves. Subsequently, we have clarified that DTCs such as zinc dimethyldithiocarbamate (ZDMC), zinc diethyldithiocarbamate (ZDEC) and zinc dibutyldithiocarbamate (ZDBC) and amines such as dimethylamine (DMA), diethylamine (DEA) and piperidine (PIP) were also causative in cases from surgical rubber gloves. Thus, our investigative studies revealed that, although thiurams have been taken much more notice of as allergenic compounds than their corresponding DTCs and amines, not only DTCs such as ZDMC, ZDEC, ZDBC and ZEPC, but also amines such as DMA, DEA and PIP were noteworthy causative candidates of allergic contact dermatitis from rubber gloves.
M Kaniwa; K Isama; A Nakamura; H Kantoh; K Hosono; M Itoh; K Shibata; T Usuda; K Asahi; T Osada
Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  31     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1995-06-22     Completed Date:  1995-06-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  65-71     Citation Subset:  IM    
National Institute of Hygienic Sciences, Tokyo, Japan.
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MeSH Terms
Dermatitis, Allergic Contact / diagnosis*,  etiology
Dermatitis, Occupational / diagnosis*,  etiology
Facial Dermatoses / chemically induced,  immunology
Hand Dermatoses / chemically induced,  immunology
Health Personnel*
Middle Aged
Patch Tests*
Rubber / adverse effects*
Reg. No./Substance:

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