Document Detail

Identification of caseins in goat milk.
MedLine Citation:
PMID:  12112854     Owner:  NLM     Status:  MEDLINE    
The importance of goat milk in infant diet is growing, because it is reported that goat's milk in some cases is less allergenic than cow's milk. This is due probably to the lower presence of caseins associated with a specific type of alpha(s1)-casein. In caprine breeds, four types of alpha(s1)-casein alleles are identified and associated with various amounts of this protein in milk. The contribution of strong alleles to the goat milk is approximately 3.6 g/L of alpha(s1)-casein, while for middle alleles is only 1.6 g/L, weak alleles 0.6 g/L. The contribution of null allele is very low (or non-existent). The quantity of total caseins in caprine milk is positively correlated with the amount of alpha(s1)-casein. Milk from animals possessing strong alleles contain significantly more total caseins than milk from animals without those alleles. This is important because animals with mild alleles can be employed to produce milk for allergic subjects while the other animals can be used to produce milk for the dairy industry. This work shows casein profiles of two types of classified goat milk (B, strong alpha(s1) allele, 0, null alpha(s1) allele) with two-dimensional electrophoresis coupled with matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and it confirms the different polymorphisms at locus alpha(s1) casein.
Paola Roncada; Alessandro Gaviraghi; Sabrina Liberatori; Benito Canas; Luca Bini; Gian Franco Greppi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proteomics     Volume:  2     ISSN:  1615-9853     ISO Abbreviation:  Proteomics     Publication Date:  2002 Jun 
Date Detail:
Created Date:  2002-07-11     Completed Date:  2003-01-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101092707     Medline TA:  Proteomics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  723-6     Citation Subset:  IM    
Laboratorio Analisi Proteomica, Istituto di Medicina Legale e Legislazione Veterinaria, Università degli Studi di Milano, Milano, Italy.
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MeSH Terms
Caseins / chemistry*,  genetics
Electrophoresis, Gel, Two-Dimensional / methods*
Isoelectric Focusing / methods
Mass Spectrometry
Milk / chemistry*
Milk Proteins / chemistry*
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Reg. No./Substance:
0/Caseins; 0/Milk Proteins

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