Document Detail


Identification of candidate markers on bovine chromosome 14 (BTA14) under milk production trait quantitative trait loci in Holstein.
MedLine Citation:
PMID:  21749477     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The objective of this study was to identify single-nucleotide polymorphisms using a bovine chromosome 14 high-density SNP panel after accounting for the effect of DGAT1. Linkage disequilibrium information and sire heterozygosity were used to select markers for linkage analysis on bovine chromosome 14 for milk production traits in 321 Holstein animals. Results show putative milk peaks at 42 and 61 cM, both at p < 0.10, a fat yield peak at 42 and 63 cM, both at p < 0.05; a protein yield peak at 42 (p < 0.01) and 84 cM (p < 0.05); fat per cent peaks at 3 (p < 0.01) and 29 cM (p < 0.05), and a protein per cent peak at 4 cM (p < 0.05). Once quantitative trait loci positions were established, allele substitution effects for all markers were evaluated using the same statistical model. Overlaying information between quantitative trait loci (QTL) and allele effect analysis enabled the identification (p < 0.01) of 20 SNPs under the milk yield QTL, 2 under both of the fat yield peaks, 8 and 9 under the protein yield peaks, 2 and 6 for the fat per cent peaks and 5 for the protein per cent peak. One SNP in particular, ss61514555:A>C, showed association with 3 of the 5 traits: milk (p = 1.59E-04), fat (p = 6.88E-05) and protein yields (p = 5.76E-05). Overall, combining information from linkage disequilibrium, sire heterozygosity and genetic knowledge of traits enabled the characterization of additional markers with significant associations with milk production traits.
Authors:
E Marques; J R Grant; Z Wang; D Kolbehdari; P Stothard; G Plastow; S S Moore
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Publication Detail:
Type:  Journal Article     Date:  2011-04-13
Journal Detail:
Title:  Journal of animal breeding and genetics = Zeitschrift für Tierzüchtung und Züchtungsbiologie     Volume:  128     ISSN:  1439-0388     ISO Abbreviation:  J. Anim. Breed. Genet.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100955807     Medline TA:  J Anim Breed Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  305-13     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Verlag GmbH.
Affiliation:
Department of Agricultural, Life and Environmental Sciences, University of Alberta, Edmonton, AB, Canada  Beefbooster Inc, Calgary, AB, Canada  Monsanto Company, Ankeny, IA, USA.
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