Document Detail

Identification of calcifications in cardiac valves by near infrared Raman spectroscopy.
MedLine Citation:
PMID:  17803386     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The objective of this work was to detect calcification in cardiac valves using near infrared Raman spectroscopy (NIRS). A Ti:sapphire laser pumped by an argon-ion laser operating at a wavelength of 830 nm was used for excitation of the valve samples, and Raman emission was detected by an optical spectrometer with a liquid nitrogen-cooled CCD detector. BACKGROUND: Cardiac valves are subjected to highly repetitive mechanical stresses, due to their over 40 million cardiac cycles per year. These structures may suffer cumulative lesions, complicated by the deposition of calcium phosphate, which can lead to clinically significant diseases. NIRS can provide important information about biological tissue composition and has been used for diagnosis of some types of human pathology. METHODS: Samples of normal and pathologic tissues 5 mm in size were analyzed. RESULTS: It was observed that the Raman spectrum of calcified cardiac valves presented different behavior when compared with normal valves. Differences were observed at the intensity of 960, 1,260, 1,452, and 1,660 cm(1) peaks. CONCLUSIONS: These results suggest that this technique could be used to detect calcium phosphate mineral deposition in cardiac valves.
Rick Rocha; Antonio Balbin Villaverde; Carlos Augusto Pasqualucci; Landulfo Silveira; Aldo Brugnera; Maricilia S Costa; Marcos Tadeu T Pacheco
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Photomedicine and laser surgery     Volume:  25     ISSN:  1549-5418     ISO Abbreviation:  -     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-06     Completed Date:  2007-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  101222340     Medline TA:  Photomed Laser Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  287-90     Citation Subset:  IM    
Instituto de Pesquisa & Desenvolvimento (IP&D), Universidade do Vale do Paraíba - UNIVAP, Urbanova, São José dos Campos, SP, Brazil.
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MeSH Terms
Analysis of Variance
Calcinosis / diagnosis*,  pathology
Coronary Artery Disease / diagnosis*,  pathology
Coronary Vessels / chemistry,  pathology*
Spectrum Analysis, Raman*

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