Document Detail


Identification of c-MYC as a target of the APC pathway.
MedLine Citation:
PMID:  9727977     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The adenomatous polyposis coli gene (APC) is a tumor suppressor gene that is inactivated in most colorectal cancers. Mutations of APC cause aberrant accumulation of beta-catenin, which then binds T cell factor-4 (Tcf-4), causing increased transcriptional activation of unknown genes. Here, the c-MYC oncogene is identified as a target gene in this signaling pathway. Expression of c-MYC was shown to be repressed by wild-type APC and activated by beta-catenin, and these effects were mediated through Tcf-4 binding sites in the c-MYC promoter. These results provide a molecular framework for understanding the previously enigmatic overexpression of c-MYC in colorectal cancers.
Authors:
T C He; A B Sparks; C Rago; H Hermeking; L Zawel; L T da Costa; P J Morin; B Vogelstein; K W Kinzler
Related Documents :
2482227 - Activation of transcription by v-myb: evidence for two different mechanisms.
14582157 - Transcripts from the cellular homologs of retroviral oncogenes: distribution among chic...
9727977 - Identification of c-myc as a target of the apc pathway.
2323837 - N-myc gene is amplified in alveolar rhabdomyosarcomas (rms) but not in embryonal rms.
8415697 - Regional expression and chromosomal localization of the delta opiate receptor gene.
19026987 - Mutations of lysophosphatidic acid receptor-1 gene during progression of lung tumors in...
Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  281     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1998-09-21     Completed Date:  1998-09-21     Revised Date:  2009-10-27    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1509-12     Citation Subset:  IM    
Affiliation:
Howard Hughes Medical Institute and Johns Hopkins Oncology Center, 424 North Bond Street, Baltimore, MD 21231, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyposis Coli Protein
Binding Sites
Cell Line
Colorectal Neoplasms / genetics*
Cytoskeletal Proteins / genetics,  metabolism
Gene Expression Regulation, Neoplastic*
Genes, APC*
Genes, Reporter
Genes, myc*
HT29 Cells
Humans
Mutation
Promoter Regions, Genetic
Proto-Oncogene Proteins c-myc / metabolism
Signal Transduction
TCF Transcription Factors
Trans-Activators*
Transcription Factors / metabolism
Transcription, Genetic
beta Catenin
Grant Support
ID/Acronym/Agency:
CA57345/CA/NCI NIH HHS; CA62924/CA/NCI NIH HHS; GM07309/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Adenomatous Polyposis Coli Protein; 0/CTNNB1 protein, human; 0/Cytoskeletal Proteins; 0/Proto-Oncogene Proteins c-myc; 0/TCF Transcription Factors; 0/Tcf7L2 transcription factor; 0/Trans-Activators; 0/Transcription Factors; 0/beta Catenin
Comments/Corrections
Comment On:
Science. 1998 Sep 4;281(5382):1438-9, 1441   [PMID:  9750112 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV.
Next Document:  Extrapolating species abundance across spatial scales