| Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi. | |
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MedLine Citation:
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PMID: 18295599 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bacterial quorum sensing plays a very important role in the regulation of biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe for the first time the discovery of several boronic acids as single digit micromolar inhibitors of bacterial quorum sensing in Vibrio harveyi. |
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Authors:
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Nanting Ni; Han-Ting Chou; Junfeng Wang; Minyong Li; Chung-Dar Lu; Phang C Tai; Binghe Wang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-02-22 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 369 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-03-25 Completed Date: 2008-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 590-4 Citation Subset: IM |
Affiliation:
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Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, Atlanta, GA 30302-4098, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Boronic Acids
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administration & dosage* Dose-Response Relationship, Drug Quorum Sensing / drug effects, physiology* Vibrio / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Boronic Acids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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