Document Detail

Identification of bile alcohols in serum from healthy humans.
MedLine Citation:
PMID:  3242175     Owner:  NLM     Status:  MEDLINE    
Bile alcohol glucuronides present in human serum were isolated by ion exchange chromatography on piperidino-hydroxypropyl Sephadex LH-20. Following hydrolysis with beta-glucuronidase, the bile alcohols were analyzed by a combination of gas-liquid chromatography and mass spectrometry. Bile alcohols identified were 27-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25-pentol, 27-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25,26-hexol, 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25-pentol, 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,26-pentol, 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25,26-pentol, and 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25,26-hexol. The bile alcohol composition in serum was similar to that in urine but not to that in bile. The concentration of total bile alcohols in serum was 59.5 +/- 24.6 micrograms/L.
T Hiraoka; K Kihira; D Kosaka; T Kohda; T Hoshita; G Kajiyama
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Steroids     Volume:  51     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:    1988 May-Jun
Date Detail:
Created Date:  1989-05-16     Completed Date:  1989-05-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  543-50     Citation Subset:  IM    
First Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
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MeSH Terms
Bile / metabolism
Cholestanols / blood*,  isolation & purification
Chromatography, Ion Exchange
Gas Chromatography-Mass Spectrometry
Kidney / metabolism
Reg. No./Substance:

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