| Identification of bile alcohols in serum from healthy humans. | |
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MedLine Citation:
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PMID: 3242175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bile alcohol glucuronides present in human serum were isolated by ion exchange chromatography on piperidino-hydroxypropyl Sephadex LH-20. Following hydrolysis with beta-glucuronidase, the bile alcohols were analyzed by a combination of gas-liquid chromatography and mass spectrometry. Bile alcohols identified were 27-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25-pentol, 27-nor-5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25,26-hexol, 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25-pentol, 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,26-pentol, 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25,26-pentol, and 5 beta-cholestane-3 alpha,7 alpha,12 alpha,24,25,26-hexol. The bile alcohol composition in serum was similar to that in urine but not to that in bile. The concentration of total bile alcohols in serum was 59.5 +/- 24.6 micrograms/L. |
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Authors:
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T Hiraoka; K Kihira; D Kosaka; T Kohda; T Hoshita; G Kajiyama |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Steroids Volume: 51 ISSN: 0039-128X ISO Abbreviation: Steroids Publication Date: 1988 May-Jun |
Date Detail:
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Created Date: 1989-05-16 Completed Date: 1989-05-16 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 543-50 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Hiroshima University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bile / metabolism Cholestanols / blood*, isolation & purification Chromatography, Ion Exchange Female Gas Chromatography-Mass Spectrometry Humans Kidney / metabolism Male |
| Chemical | |
Reg. No./Substance:
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0/Cholestanols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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