Document Detail


Identification of asthma clusters in two independent Korean adult asthma cohorts.
MedLine Citation:
PMID:  23060627     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Asthma is a heterogeneous airway disease with various clinical phenotypes. It is crucial to clearly identify clinical phenotypes to achieve better asthma management.We used cluster analysis to classify the clinical groups of 724 asthmatic patients from the Korean Cohort for Reality and Evolution of adult Asthma (COREA), and in 1843 subjects from another independent Korean asthma cohort of Soonchunhyang University Hospitals (SCH cohort). Hierarchical cluster analysis was performed by Ward's method, followed by k-means cluster analysis.Cluster analysis of the COREA cohort indicated four asthma subtypes: (i) smoking asthma, (ii) severe obstructive asthma, (iii) early-onset atopic asthma, and (iv) late-onset mild asthma. An independent cluster analysis of the SCH cohort also indicated four clusters that were similar to the COREA clusters.Our results indicate that adult Korean asthma patients can be classified into four distinct clusters.
Authors:
Tae-Bum Kim; An-Soo Jang; Hyouk-Soo Kwon; Jong-Sook Park; Yoon-Seok Chang; Sang-Heon Cho; Byoung Whui Choi; Jung Won Park; Dong-Ho Nam; Ho-Joo Yoon; Young-Joo Cho; Hee-Bom Moon; You Sook Cho; Choon-Sik Park;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Dept of Internal Medicine, Asthma Center in Asan Medical Center, University of Ulsan College of Medicine, Seoul.
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