Document Detail

Identification and analysis of novel amino acid sequence repeats and domains in Pyrobaculum aerophilum using computational tools.
MedLine Citation:
PMID:  17897095     Owner:  NLM     Status:  MEDLINE    
We have identified four repeats and five domains that are novel in proteins encoded by the Pyrobaculum aerophilum str. IM2 proteome using automated in silico methods. A "repeat" corresponds to a region comprising less than 55 amino acid residues that occurs more than once in the protein sequence and sometimes present in tandem. A "domain" corresponds to a conserved region comprising greater than 55 amino acid residues and may be present as single or multiple copies in the protein sequence. These correspond to (1) 85 amino acid residues AAG domain, (2) 72 amino acid residues GFGN domain, (3) 43 amino acid residues KGG repeat, (4) 25 amino acid residues RWE repeat, (5) 25 amino acid residues RID repeat, (6) 108 amino acid residues NDFA domain, (7) 140 amino acid residues VxY domain, (8) 35 amino acid residues LLPN repeat and (9) 98 amino acid residues GxY domain. A repeat or domain is characterized by specific conserved sequence motifs. We discuss the presence of these repeats and domains in proteins from other genomes and their probable secondary structure.
Golaconda Hemalatha; Inampudi Krishna Kishore; Raghavarapu Srinivasa Rao; Lalitha Guruprasad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Protein and peptide letters     Volume:  14     ISSN:  0929-8665     ISO Abbreviation:  Protein Pept. Lett.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-27     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9441434     Medline TA:  Protein Pept Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  692-7     Citation Subset:  IM    
School of Chemistry, University of Hyderabad, Hyderabad 500046, India.
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MeSH Terms
Amino Acid Sequence
Archaeal Proteins / chemistry*
Crystallography, X-Ray
Molecular Sequence Data
Pyrobaculum / chemistry*
Repetitive Sequences, Amino Acid
Sequence Homology, Amino Acid
Reg. No./Substance:
0/Archaeal Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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