Document Detail

Identification of melamine/cyanuric acid-containing nephrolithiasis by infrared spectroscopy.
MedLine Citation:
PMID:  20333762     Owner:  NLM     Status:  MEDLINE    
Melamine-contaminated milk formula caused infant nephrolithiasis in some areas of China. Its combination with cyanuric acid causes crystallization in renal tubules. Following this renal damage and even renal failure that require long-term hemodialysis has been reported. Therefore, correct and timely diagnosis of these complex diseases is critical. Melamine containing stone is a combination of equal molar ratios of common stone compositions that has been reported from previous animal studies. We have previously identified the compositions of urinary tract stones with infrared (IR) spectroscopy. We hypothesized that the absorbance of wavelength of IR can identify melamine/cyanuric acid in the presence of mixing human stone compositions. In this study, we made an artificial stone composition and examine under IR absorbance by mixing equal molar ratios of melamine/cyanuric acid with different types of human urinary stones, and established a reference of IR analysis for the identification of melamine/cyanuric acid-containing human urinary tract stones. Knowledge of the precise stone composition allowed institution of appropriate prophylactic dietary and medical therapy and this may help in the prevention of urinary stone recurrence. The results are promising that melamine and cyanuric acid can be identified clearly in a low percentile (approximately 1%) of stone mixture pellet. Therefore, IR seems to be an ideal tool for the identification of melamine/cyanuric acid-containing stones.
Wen-Chi Chen; San-Yuan Wu; Hsin-Ping Liu; Chiao-Hui Chang; Huey-Yi Chen; Hsin-Yi Chen; Chou-Huang Tsai; Yi-Chun Chang; Fuu-Jen Tsai; Kee-Ming Man; Po-Len Liu; Feng-Yen Lin; Jui-Lung Shen; Wei-Yong Lin; Yung-Hsiang Chen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical laboratory analysis     Volume:  24     ISSN:  1098-2825     ISO Abbreviation:  J. Clin. Lab. Anal.     Publication Date:  2010  
Date Detail:
Created Date:  2010-03-29     Completed Date:  2010-06-22     Revised Date:  2010-09-30    
Medline Journal Info:
Nlm Unique ID:  8801384     Medline TA:  J Clin Lab Anal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  92-9     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
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MeSH Terms
Food Contamination / analysis
Kidney Calculi / chemistry*,  metabolism
Nephrolithiasis / diagnosis*,  etiology,  metabolism
Spectrophotometry, Infrared / methods*
Triazines / analysis*,  metabolism
Reg. No./Substance:
0/Triazines; 108-78-1/melamine; 108-80-5/cyanuric acid

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