Document Detail


Identification of X-linked quantitative trait loci affecting cold tolerance in Drosophila melanogaster and fine mapping by selective sweep analysis.
MedLine Citation:
PMID:  21199023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Drosophila melanogaster is a cosmopolitan species that colonizes a great variety of environments. One trait that shows abundant evidence for naturally segregating genetic variance in different populations of D. melanogaster is cold tolerance. Previous work has found quantitative trait loci (QTL) exclusively on the second and the third chromosomes. To gain insight into the genetic architecture of cold tolerance on the X chromosome and to compare the results with our analyses of selective sweeps, a mapping population was derived from a cross between substitution lines that solely differed in the origin of their X chromosome: one originates from a European inbred line and the other one from an African inbred line. We found a total of six QTL for cold tolerance factors on the X chromosome of D. melanogaster. Although the composite interval mapping revealed slightly different QTL profiles between sexes, a coherent model suggests that most QTL overlapped between sexes, and each explained around 5-14% of the genetic variance (which may be slightly overestimated). The allelic effects were largely additive, but we also detected two significant interactions. Taken together, this provides evidence for multiple QTL that are spread along the entire X chromosome and whose effects range from low to intermediate. One detected transgressive QTL influences cold tolerance in different ways for the two sexes. While females benefit from the European allele increasing their cold tolerance, males tend to do better with the African allele. Finally, using selective sweep mapping, the candidate gene CG16700 for cold tolerance colocalizing with a QTL was identified.
Authors:
Nicolas Svetec; Annegret Werzner; Ricardo Wilches; Pavlos Pavlidis; José M Alvarez-Castro; Karl W Broman; Dirk Metzler; Wolfgang Stephan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-24
Journal Detail:
Title:  Molecular ecology     Volume:  20     ISSN:  1365-294X     ISO Abbreviation:  Mol. Ecol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-18     Completed Date:  2012-03-15     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  9214478     Medline TA:  Mol Ecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  530-44     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Affiliation:
Section of Evolutionary Biology, Biocenter, University of Munich, 82152 Planegg-Martinsried, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / genetics*
Animals
Chromosome Mapping
Cold Temperature
Drosophila Proteins / genetics*
Drosophila melanogaster / genetics*,  physiology
Female
Genes, X-Linked*
Genetic Variation
Hot Temperature
Male
Models, Genetic
Phenotype
Quantitative Trait Loci / genetics*
X Chromosome / genetics
Grant Support
ID/Acronym/Agency:
GM074244/GM/NIGMS NIH HHS; R01 GM074244/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Drosophila Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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