Document Detail


Identification of stem-like cells in head and neck cancer cell lines.
MedLine Citation:
PMID:  20651344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the existence of stem-like cells in established head and neck squamous cell carcinoma (HNSCC) lines, HSC3 and HSC4. Flow cytometric analysis confirmed the presence of side population (SP) cells excluding Hoechst 33342 in HSC4 cells (0.37+/-0.06%) but not HSC3 cells in a reserpine-sensitive manner. After sorting, the SP cells generated both SP and main population (MP) cells in culture while MP cells generated MP cells only. Higher expression of stem cell markers was detected in SP than in MP cells. These results suggest that cancer stem-like cells exist in head and neck squamous cell carcinoma.
Authors:
Guangwei Sun; Masato Fujii; Akira Sonoda; Yutaka Tokumaru; Tatsuo Matsunaga; Noboru Habu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anticancer research     Volume:  30     ISSN:  1791-7530     ISO Abbreviation:  Anticancer Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-07-23     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  2005-10     Citation Subset:  IM    
Affiliation:
Division of Hearing and Balance Research, National Institute of Sensory Organs, National Tokyo Medical Center, Meguro, Tokyo 152-8902, Japan.
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MeSH Terms
Descriptor/Qualifier:
ATP-Binding Cassette Transporters / analysis
Antigens, CD44 / analysis
Carcinoma, Squamous Cell / pathology*
Cell Line, Tumor
Flow Cytometry
Head and Neck Neoplasms / pathology*
Humans
Neoplasm Proteins / analysis
Neoplastic Stem Cells / pathology*
beta Catenin / analysis
Chemical
Reg. No./Substance:
0/ABCG2 protein, human; 0/ATP-Binding Cassette Transporters; 0/Antigens, CD44; 0/CD44 protein, human; 0/Neoplasm Proteins; 0/beta Catenin

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