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Identification of SNPs within the sheep PROP1 gene and their effects on wool traits.
MedLine Citation:
PMID:  21104025     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Regarding mutations of PROP1 (Prophet of POU1F1) gene significantly associating with combined pituitary hormone deficiency (CPHD) in human patients and animals, PROP1 gene is a novel important candidate gene for detecting genetic variation and growth, reproduction, metabolism traits selection and breeding. The aim of this study was to detect PROP1 gene mutation of the exon 1-3 and its association with wool traits in 345 Chinese Merino sheep. In this study, on the basis of PCR-SSCP and DNA sequencing methods, ten novel SNPs within the sheep PROP1 gene, namely, AY533708: g.45A > G resulting in Glu15Glu, g.1198A > G, g.1341G > C resulting in Arg63Ser, g.1389G > A resulting in Ala79Ala, g.1402C > T resulting in Leu84Leu, g.1424A > G resulting in Asn91Ser, g.1522C > T, g.1556A > T, g.1574T > C, g.2430C > G were reported. In addition, association analysis showed that three genotypes of P4 fragment were significantly associated with fiber diameter in the analyzed population (P = 0.044). These results strongly suggested that polymorphisms of the PROP1 gene could be a useful molecular marker for sheep breeding and genetics through marker-assisted selection (MAS).
Authors:
Xian-Cun Zeng; Han-Ying Chen; Bin Jia; Zong-Sheng Zhao; Wen-Qiao Hui; Zun-Bao Wang; Ying-Chun Du
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Publication Detail:
Type:  Journal Article     Date:  2010-11-20
Journal Detail:
Title:  Molecular biology reports     Volume:  38     ISSN:  1573-4978     ISO Abbreviation:  Mol. Biol. Rep.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2723-8     Citation Subset:  IM    
Affiliation:
College of Animal Science and Technology, Shihezi University, Shihezi, 832003, Xinjiang, People's Republic of China, Zengxiancun0993@sina.com.
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