Document Detail


Identification of (Poly)phenolic Compounds in Concord Grape Juice and Their Metabolites in Human Plasma and Urine after Juice Consumption.
MedLine Citation:
PMID:  21812481     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Analysis of Concord grape juice by HPLC with ESI-MSn, PDA and fluorescence detection resulted in the identification and quantification of 60 flavonoids and related phenolic compounds which were present at an overall concentration of 1508 ± 31 µmol/L. A total of 25 anthocyanins were detected, which were mono- and di-O-glucosides, O-acetylglucosides, O-p-coumaroyl-O-diglucosides and O-p-coumaroylglucosides of delphinidin, cyanidin, petunidin, peonidin and malvidin. The anthocyanins represented 46% of the total phenolic content of the juice (680 µmol/L). Tartaric esters of hydroxycinnamic acids, namely trans-caftaric and trans-coutaric acids, and to a lesser extend trans-fertaric acid, accounted for 29% of the phenolic content, with a total concentration of 444 µmol/L, of which 85% comprised of trans-caftaric acid. Free hydroxycinnamic acids were also quantified but at 8.4 µmol/L contributed less than 1% of the total phenolic content. The other groups of polyphenolic compounds present in the juice, accounting for 24% of the total, comprised of monomeric and oligomeric units of (epi)catechin and (epi)gallocatechin (248 µmol/L), flavonols (76 µmol/L), gallic acid (51 µmol/L) and trans-resveratrol (1.5 µmol/L). The bioavailability of the (poly)phenolic compounds in 350 mL of juice was investigated following acute intake by healthy volunteers. Plasma and urine were collected over 0-24-h and analysed for parent compounds and metabolites. In total 41 compounds, principally metabolites, were identified.
Authors:
Angelique Stalmach; Christine Edwards; Jolynne Wightman; Alan Crozier
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-3
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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