| Identification of (Poly)phenolic Compounds in Concord Grape Juice and Their Metabolites in Human Plasma and Urine after Juice Consumption. | |
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MedLine Citation:
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PMID: 21812481 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Analysis of Concord grape juice by HPLC with ESI-MSn, PDA and fluorescence detection resulted in the identification and quantification of 60 flavonoids and related phenolic compounds which were present at an overall concentration of 1508 ± 31 µmol/L. A total of 25 anthocyanins were detected, which were mono- and di-O-glucosides, O-acetylglucosides, O-p-coumaroyl-O-diglucosides and O-p-coumaroylglucosides of delphinidin, cyanidin, petunidin, peonidin and malvidin. The anthocyanins represented 46% of the total phenolic content of the juice (680 µmol/L). Tartaric esters of hydroxycinnamic acids, namely trans-caftaric and trans-coutaric acids, and to a lesser extend trans-fertaric acid, accounted for 29% of the phenolic content, with a total concentration of 444 µmol/L, of which 85% comprised of trans-caftaric acid. Free hydroxycinnamic acids were also quantified but at 8.4 µmol/L contributed less than 1% of the total phenolic content. The other groups of polyphenolic compounds present in the juice, accounting for 24% of the total, comprised of monomeric and oligomeric units of (epi)catechin and (epi)gallocatechin (248 µmol/L), flavonols (76 µmol/L), gallic acid (51 µmol/L) and trans-resveratrol (1.5 µmol/L). The bioavailability of the (poly)phenolic compounds in 350 mL of juice was investigated following acute intake by healthy volunteers. Plasma and urine were collected over 0-24-h and analysed for parent compounds and metabolites. In total 41 compounds, principally metabolites, were identified. |
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Authors:
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Angelique Stalmach; Christine Edwards; Jolynne Wightman; Alan Crozier |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-3 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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