Document Detail

Identification of N-epsilon-(2-propenal)lysine as the main form of malondialdehyde in food digesta.
MedLine Citation:
PMID:  3125998     Owner:  NLM     Status:  MEDLINE    
The form(s) in which malondialdehyde (MDA), a mutagenic product of the oxidative decomposition of polyunsaturated fatty acids (PUFA), occurs in foods was investigated. Several foods of animal origin (ground beef, smoked fish, chicken, sausages) were digested in vitro using pepsin and porcine intestinal fluid and the occurrence of MDA derivatives in the digesta was investigated by thin-layer, column and high-performance liquid chromatography. The predominant form of MDA was shown to be identical to synthetic N-epsilon-propenal lysine. This compound is apparently formed by a reaction between free MDA generated as a product of the oxidative rancidity of PUFA in foods and the free epsilon-amino groups of proteins, from which it is released in the course of digestion. It has been shown to be excreted in rat and human urine partially in the unchanged form and partially as the N-alpha-acetyl derivative. The results of this study serve to mitigate concern over the possible carcinogenicity of MDA in the diet, since less than 10% of the MDA in several foods containing highly unsaturated fatty acids was found in the free form.
L A Piche; P D Cole; M Hadley; R van den Bergh; H H Draper
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  9     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-04-14     Completed Date:  1988-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  IM    
Department of Nutritional Sciences, College of Biological Science, University of Guelph, Ontario, Canada.
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MeSH Terms
Chromatography, High Pressure Liquid
Chromatography, Thin Layer
Food Analysis*
Lysine / analogs & derivatives*,  analysis,  metabolism
Malonates / metabolism*
Malondialdehyde / metabolism*
Meat / analysis
Reg. No./Substance:
0/Malonates; 542-78-9/Malondialdehyde; 56-87-1/Lysine; 99124-76-2/N-epsilon-(2-propenal)lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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