Document Detail

Identification of MFS proteins in sorghum using semantic similarity.
MedLine Citation:
PMID:  23299296     Owner:  NLM     Status:  Publisher    
The antiporters, uniporters and symporters are the functional classes of MFS that play major role in ions homeostasis, regulation of pumps and channels, membrane structure, transporters activity in tolerance to abiotic stresses. Major facilitator superfamily (MFS) encodes Na(+)/H(+) antiporter that are considered as being sensors of the molecule transports. A large number of MFS proteins have been identified in several plants, rice, maize, Arabidopsis etc. However, the majority of proteins in sorghum are described as putative, uncharacterized till date. This suggested that identified proteins of MFS in sorghum are far from saturation. Hence, we developed gene ontology (GO) terms semantic similarity based method using GOSemSim measure of R package. As a result, total 2,568 high (100 %) semantic similar orthologous proteins from 7 plant species were obtained. These data were used to predict function of 257 putative uncharacterized proteins from 18 families of MFS in Sorghum. Consequently, the identified proteins belonged to the function of regulation of pumps and channels, membrane structure, transporters activity, ions homeostasis, transporter mechanisms and binding process. These identified functions appear to have a distinct mechanism of salt-stress adaptation in plants. The proposed method will help in further identifying new proteins that can help in the development of agronomically and economically important plants.
Manoj Kumar Sekhwal; Vinay Sharma; Renu Sarin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Theory in biosciences = Theorie in den Biowissenschaften     Volume:  -     ISSN:  1611-7530     ISO Abbreviation:  Theory Biosci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708216     Medline TA:  Theory Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Bioscience and Biotechnology, Banasthali University, P.O. Banasthali Vidyapith, 304022, Vanasthali, Rajasthan, India.
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