Document Detail


Identification of Legionella Effectors Using Bioinformatic Approaches.
MedLine Citation:
PMID:  23150423     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Legionella pneumophila the causative agent of Legionnaires' disease, actively manipulates host cell processes to establish a replication niche inside host cells. The establishment of its replication niche requires a functional Icm/Dot type IV secretion system which translocates about 300 effector proteins into host cells during infection. Many of these effectors were first identified as effector candidates by several bioinformatic approaches, and these predicted effectors were later examined experimentally for translocation and a large number of which were validated as effector proteins. Here, I summarized the bioinformatic approaches that were used to identify these effectors.
Authors:
Gil Segal
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  954     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  595-602     Citation Subset:  -    
Affiliation:
George S. Wise Faculty of Life Sciences, Department of Molecular MIcrobiology and Biotechnology, Tel-Aviv University, Ramat-Aviv, Israel, gils@tauex.tau.ac.il.
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