| Identification of an IFN-gamma responsive region in an intron of the invariant chain gene. | |
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MedLine Citation:
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PMID: 11009094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mechanism by which IFN-gamma up-regulates invariant chain mRNA in antigen-presenting cells has been under intensive investigation. This study shows that in murine monocytic cells the transcriptional up-regulation mediated by the invariant chain (Ii) upstream enhancer only accounts for part of the induction of Ii mRNA by IFN-gamma. We have identified an intronic region in the murine Ii gene that contributes to the transcriptional up-regulation by IFN-gamma. The region has S (H), X/X2 and Y boxes similar to those in MHC class II promoters and the Ii upstream enhancer. Mutations at the putative S, X and Y boxes have abolished the ability of the region to mediate Ii up-regulation by IFN-gamma. Consistent with the functions of these boxes, our findings reveal that the up-regulation of Ii transcription by IFN-gamma mediated by the intronic region is dependent on the induction of class II transactivator by IFN-gamma. |
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Authors:
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Z A Cao; B B Moore; D Quezada; C H Chang; P P Jones |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunology Volume: 30 ISSN: 0014-2980 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-10-12 Completed Date: 2000-10-12 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: GERMANY |
Other Details:
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Languages: eng Pagination: 2604-11 Citation Subset: IM |
Affiliation:
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Department of Biological Sciences, Stanford University, CA 94305, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antigens, Differentiation, B-Lymphocyte
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genetics* Base Sequence Cells, Cultured Histocompatibility Antigens Class II / genetics* Humans Interferon-gamma / pharmacology* Introns* Molecular Sequence Data RNA, Messenger / analysis Response Elements* Transcription, Genetic / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antigens, Differentiation, B-Lymphocyte; 0/Histocompatibility Antigens Class II; 0/RNA, Messenger; 0/invariant chain; 82115-62-6/Interferon-gamma |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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