| Identification of the Fur-Binding Site in Regulatory Region of the Vulnibactin-Receptor Gene in Vibrio vulnificus. | |
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MedLine Citation:
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PMID: 22297218 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Vibrio vulnificus vuuA gene, of which expression is repressed by a complex of iron and ferric uptake regulator (Fur), was characterized to localize the Fur-binding site in its upstream regulatory region. In silico analysis suggested the presence of two possible Fur-binding sites; one is a classical Fur-box and the other is a previously reported distinct Fur-binding site. Site-directed mutagenesis and DNase I protection assays revealed the binding site for the iron-Fur complex, which includes an extended inverted repeat containing a homologous sequence to the classical Fur-box. |
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Authors:
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Hyun-Jung Lee; Kyu-Ho Lee |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of microbiology and biotechnology Volume: 22 ISSN: 1738-8872 ISO Abbreviation: J. Microbiol. Biotechnol. Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-02-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9431852 Medline TA: J Microbiol Biotechnol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 46-9 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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