Document Detail


Identification of drug-related problems: a prospective study in two general hospitals.
MedLine Citation:
PMID:  22794158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODOLOGY: Prospective observational study was conducted to report and record the natural and frequency of drug related problems in two general hospitals.
RESULTS: The study included 212 patients, 54.4 % female, with a mean age 62.2 (±10.6 SD). 88% of the patients were reported with one or more DRPs, with an average of 1.9 DRPs per patient were found. The most prevalent DRP was incorrect dosing regimen which was represented by (22.2%), followed by drug-drug interaction (19.4%), drugs need laboratory tests (15.2%). Ceftriaxone, warfarin, enoxapirin and dogixin were the drugs causing most frequent DRPs. The drug groups causing most DRPs were anti-infective agents, anti-thrombotic agents and non-steroidal anti-inflammatory agents. Once discovered, the majority of DRPs (71.6%) were accepted by the physicians and solved immediately, while 11.5 % of pharmacist advice was not approved. Multiple regression analysis indicated that the number of medications (RR 1.99; 95% CI 1.31-3.76) and the number of medical conditions (RR 1.81; 95% CI 1.11-3.13) independently predicted the number of DRPs.
CONCLUSION: DRPs in general hospitals are frequent, serious and predictable. Most of the problems identified as DRPs by the pharmacists were accepted by the physicians and solved. Pharmacists in the hospital setting are well suited to identify and resolve DRPs.
Authors:
Maher R Khdour; Anan S Jarab; Heba O Adas; Ekhlas Z Samaro; Tareq L Mukattash; Hussein O Hallak
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Current clinical pharmacology     Volume:  7     ISSN:  2212-3938     ISO Abbreviation:  Curr Clin Pharmacol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-06-18     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101273158     Medline TA:  Curr Clin Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  276-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Drug-Related Side Effects and Adverse Reactions*
Female
Hospitals, General
Humans
Male
Middle Aged
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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