| Identification of CCDC6-RET Fusion in the Human Lung Adenocarcinoma Cell Line, LC-2/ad. | |
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MedLine Citation:
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PMID: 23154560 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rearranged during transfection (RET) fusions have been newly identified in approximately 1% of patients with primary lung tumors. However, patient-derived lung cancer cell lines harboring RET fusions have not yet been established or identified, and therefore, the effectiveness of an RET inhibitor on lung tumors with endogenous RET fusion has not yet been studied. In this study, we report identification of CCDC6-RET fusion in the human lung adenocarcinoma cell line LC-2/ad. LC-2/ad showed distinctive sensitivity to the RET inhibitor, vandetanib, among 39 non-small lung cancer cell lines. The xenograft tumor of LC-2/ad showed cribriform acinar structures, a morphologic feature of primary RET fusion-positive lung adenocarcinomas. LC-2/ad cells could provide useful resources to analyze molecular functions of RET-fusion protein and its response to RET inhibitors. |
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Authors:
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Daisuke Matsubara; Yoshihiko Kanai; Shumpei Ishikawa; Shiori Ohara; Taichiro Yoshimoto; Takashi Sakatani; Sachiko Oguni; Tomoko Tamura; Hiroaki Kataoka; Shunsuke Endo; Yoshinori Murakami; Hiroyuki Aburatani; Masashi Fukayama; Toshiro Niki |
Publication Detail:
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Type: JOURNAL ARTICLE |
Journal Detail:
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Title: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer Volume: 7 ISSN: 1556-1380 ISO Abbreviation: J Thorac Oncol Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-11-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101274235 Medline TA: J Thorac Oncol Country: - |
Other Details:
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Languages: ENG Pagination: 1872-1876 Citation Subset: - |
Affiliation:
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*Department of Pathology, Division of Integrative Pathology, Jichi Medical University, Shimotsuke, Tochigi, Japan; †Department of Cancer Biology, Division of Molecular Pathology, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo; ‡Department of Surgery, Division of General Thoracic Surgery, Jichi Medical University, Tochigi, Japan; §Department of Human Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku Tokyo; ‖Department of Pathology, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan; and ¶Laboratory for Systems Biology and Medicine, Division of Genome Science, Research Center for Advanced Science and Technology, The University of Tokyo, Meguro-ku, Tokyo, Japan. |
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