Document Detail


Identification of B2 bradykinin binding sites on cultured cortical astrocytes.
MedLine Citation:
PMID:  1895115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bradykinin was found to bind to specific high-affinity sites in cultured cortical astrocytes from rat brain, and this binding appeared to be specific for the B2 bradykinin receptor subtype. Nonlinear regression analysis of saturation experiments using a computer programme revealed a single KD of 16.6 +/- 2.6 nM and a Bmax of 352.2 +/- 30.7 fmol/mg of protein. These results indicate that astrocytes possess bradykinin receptors and that these are predominantly of the B2 subtype.
Authors:
A J Cholewinski; G Stevens; A M McDermott; G P Wilkin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  57     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-10-21     Completed Date:  1991-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1456-8     Citation Subset:  IM    
Affiliation:
Biochemistry Department, Imperial College of Science, Technology and Medicine, London, England, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / metabolism*
Binding Sites
Binding, Competitive
Bradykinin / metabolism*
Cells, Cultured
Cerebral Cortex / cytology,  metabolism*
Chemical
Reg. No./Substance:
58-82-2/Bradykinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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