Document Detail

Identification of B2 bradykinin binding sites on cultured cortical astrocytes.
MedLine Citation:
PMID:  1895115     Owner:  NLM     Status:  MEDLINE    
Bradykinin was found to bind to specific high-affinity sites in cultured cortical astrocytes from rat brain, and this binding appeared to be specific for the B2 bradykinin receptor subtype. Nonlinear regression analysis of saturation experiments using a computer programme revealed a single KD of 16.6 +/- 2.6 nM and a Bmax of 352.2 +/- 30.7 fmol/mg of protein. These results indicate that astrocytes possess bradykinin receptors and that these are predominantly of the B2 subtype.
A J Cholewinski; G Stevens; A M McDermott; G P Wilkin
Related Documents :
22933285 - Visualization of the two-step fusion process of the retrovirus avian sarcoma/leukosis v...
23107435 - Hopeahainol a attenuates memory deficits by targeting β-amyloid in app/ps1 transgenic ...
1331325 - Existence of three subtypes of bradykinin b2 receptors in guinea pig.
23057745 - Second messenger regulation of biofilm formation: breakthroughs in understanding c-di-g...
9070355 - Multiple factors contribute to the toxicity of the aromatic retinoid, ttnpb (ro 13-7410...
1893485 - Targeting of liposomes surface-modified with glycyrrhizin to the liver. i. preparation ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  57     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1991 Oct 
Date Detail:
Created Date:  1991-10-21     Completed Date:  1991-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1456-8     Citation Subset:  IM    
Biochemistry Department, Imperial College of Science, Technology and Medicine, London, England, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Astrocytes / metabolism*
Binding Sites
Binding, Competitive
Bradykinin / metabolism*
Cells, Cultured
Cerebral Cortex / cytology,  metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Quantitative and qualitative alterations of neuronal and glial intermediate filaments in rat nervous...
Next Document:  Cysts of the neuraxis of endodermal origin.