| Identification of an autophagy defect in smokers' alveolar macrophages. | |
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MedLine Citation:
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PMID: 20921532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Alveolar macrophages are essential for clearing bacteria from the alveolar surface and preventing microbe-induced infections. It is well documented that smokers have an increased incidence of infections, in particular lung infections. Alveolar macrophages accumulate in smokers' lungs, but they have a functional immune deficit. In this study, we identify an autophagy defect in smokers' alveolar macrophages. Smokers' alveolar macrophages accumulate both autophagosomes and p62, a marker of autophagic flux. The decrease in the process of autophagy leads to impaired protein aggregate clearance, dysfunctional mitochondria, and defective delivery of bacteria to lysosomes. This study identifies the autophagy pathway as a potential target for interventions designed to decrease infection rates in smokers and possibly in individuals with high environmental particulate exposure. |
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Authors:
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Martha M Monick; Linda S Powers; Katherine Walters; Nina Lovan; Michael Zhang; Alicia Gerke; Sif Hansdottir; Gary W Hunninghake |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-10-04 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 185 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-21 Completed Date: 2010-11-12 Revised Date: 2012-05-02 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 5425-35 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. martha-monick@uiowa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autophagy
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immunology* Blotting, Western Humans Macrophages, Alveolar / immunology, metabolism, pathology* Microscopy, Electron, Transmission Microscopy, Fluorescence Phagosomes / immunology, metabolism, pathology Smoking / adverse effects*, immunology*, pathology* Transfection |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL077431/HL/NHLBI NIH HHS; R01 HL079901/HL/NHLBI NIH HHS; R01 HL096625/HL/NHLBI NIH HHS; R01 HL096625/HL/NHLBI NIH HHS; R01 HL096625-01A1/HL/NHLBI NIH HHS; R01 HL096625-02/HL/NHLBI NIH HHS; UL1RR024979/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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