Document Detail

Identification of 46 novel SNPs in the 130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21.
MedLine Citation:
PMID:  12920609     Owner:  NLM     Status:  MEDLINE    
We identified a total of 187 single-nucleotide polymorphisms (SNPs) at 11 gene loci in the 130-kb region on chromosome 6p21 containing a gene strongly associated with myocardial infarction (MI). By comparing our data with SNPs deposited in the dbSNP database at the National Center for Biotechnology Information, 46 of these SNPs (24.6%) were considered to be novel: four were identified in the P5-1 locus, 14 in the MICB locus, nine in the BAT1 locus, one in the ATP6V1G2 locus, six in the NFKBIL1 locus, one in the LTA locus, one in the TNF locus, five in the LST1 locus, four in the LY117a locus, and one in the AIF-1 locus. The SNP map presented here should provide as useful resource not only for examining the relationships between genotypes and susceptibility to the MI phenotype, but also for scanning of complex diseases mapped to this local segment on chromosome 6.
Aritoshi Iida; Kouichi Ozaki; Yozo Ohnishi; Toshihiro Tanaka; Yusuke Nakamura
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-08-13
Journal Detail:
Title:  Journal of human genetics     Volume:  48     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-02     Completed Date:  2003-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  476-9     Citation Subset:  IM    
Laboratory for Genotyping, RIKEN SNP Research Center, Kanagawa, Japan.
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MeSH Terms
3' Untranslated Regions / genetics
5' Untranslated Regions / genetics
Case-Control Studies
Chromosome Mapping*
Chromosomes, Human, Pair 6*
Disease Susceptibility
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Myocardial Infarction / genetics*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Reg. No./Substance:
0/3' Untranslated Regions; 0/5' Untranslated Regions; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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