Document Detail


Identification of 46 novel SNPs in the 130-kb region containing a myocardial infarction susceptibility gene on chromosomal band 6p21.
MedLine Citation:
PMID:  12920609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We identified a total of 187 single-nucleotide polymorphisms (SNPs) at 11 gene loci in the 130-kb region on chromosome 6p21 containing a gene strongly associated with myocardial infarction (MI). By comparing our data with SNPs deposited in the dbSNP database at the National Center for Biotechnology Information, 46 of these SNPs (24.6%) were considered to be novel: four were identified in the P5-1 locus, 14 in the MICB locus, nine in the BAT1 locus, one in the ATP6V1G2 locus, six in the NFKBIL1 locus, one in the LTA locus, one in the TNF locus, five in the LST1 locus, four in the LY117a locus, and one in the AIF-1 locus. The SNP map presented here should provide as useful resource not only for examining the relationships between genotypes and susceptibility to the MI phenotype, but also for scanning of complex diseases mapped to this local segment on chromosome 6.
Authors:
Aritoshi Iida; Kouichi Ozaki; Yozo Ohnishi; Toshihiro Tanaka; Yusuke Nakamura
Related Documents :
14679089 - Single nucleotide polymorphism study of iddm 17 in a bedouin arab family.
25296379 - Alternative meiotic chromatid segregation in the holocentric plant luzula elegans.
15718249 - Nod1 variation, immunoglobulin e and asthma.
22542849 - Effect of linkage between vwa and d12s391 in kinship analysis.
18612189 - Genetic variations of mrf-2/arid5b confer risk of coronary atherosclerosis in the japan...
25227289 - De novo structure variations of the y chromosome in a 47,xxy female with ovarian failur...
6890559 - Spindle microtubules and their mechanical associations after micromanipulation in anaph...
7604849 - Characterization of an unbalanced de novo rearrangement by microsatellite polymorphism ...
3276139 - Del(14)(q22) in diffuse b-cell lymphocytic lymphoma.
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2003-08-13
Journal Detail:
Title:  Journal of human genetics     Volume:  48     ISSN:  1434-5161     ISO Abbreviation:  J. Hum. Genet.     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-02     Completed Date:  2003-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9808008     Medline TA:  J Hum Genet     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  476-9     Citation Subset:  IM    
Affiliation:
Laboratory for Genotyping, RIKEN SNP Research Center, Kanagawa, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
3' Untranslated Regions / genetics
5' Untranslated Regions / genetics
Case-Control Studies
Chromosome Mapping*
Chromosomes, Human, Pair 6*
Disease Susceptibility
Exons
Genetic Markers / genetics
Genetic Predisposition to Disease / genetics*
Humans
Introns
Myocardial Infarction / genetics*
Polymerase Chain Reaction
Polymorphism, Single Nucleotide*
Chemical
Reg. No./Substance:
0/3' Untranslated Regions; 0/5' Untranslated Regions; 0/Genetic Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Colicin S8 export: extracellular and cytoplasmic colicin are different.
Next Document:  Effect of dentinal pretreatments on coronal dentin primary carious lesions: a field emission SEM stu...