Document Detail

Idarubicin administered during pregnancy: its effects on the fetus.
MedLine Citation:
PMID:  15256824     Owner:  NLM     Status:  MEDLINE    
Acute myeloblastic leukemia, subtype M1, was diagnosed in a 39-year-old G2P1 Japanese woman at 21 weeks' gestation. Remission-induction polychemotherapy, including daunorubicin, performed for one cycle, did not lead to remission. Second-line chemotherapy, including idarubicin, performed for one cycle, was administrated during the early third trimester of pregnancy. Septic shock occurred due to severe myelosuppression. An emergent cesarean section was performed in response to a nonreassuring pattern of the fetal heart rate and a rapid decrease in fetal amniotic fluid. The neonate delivered at 32 weeks' gestation showed no signs of cardiac failure but did show signs of transient myelosuppression, hepatopathy, and elevated creatine kinase. Complete remission was established with idarubicin including chemotherapy.
Koji Matsuo; Koichiro Shimoya; Shuji Ueda; Kazuko Wada; Masayasu Koyama; Yuji Murata
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2004-07-14
Journal Detail:
Title:  Gynecologic and obstetric investigation     Volume:  58     ISSN:  0378-7346     ISO Abbreviation:  Gynecol. Obstet. Invest.     Publication Date:  2004  
Date Detail:
Created Date:  2004-11-16     Completed Date:  2005-04-11     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900587     Medline TA:  Gynecol Obstet Invest     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  186-8     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2004 S. Karger AG, Basel.
Department of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita City, Osaka 565-0871, Japan.
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MeSH Terms
Antibiotics, Antineoplastic / administration & dosage,  adverse effects*
Antineoplastic Combined Chemotherapy Protocols / administration & dosage,  adverse effects*
Cesarean Section
Drug Therapy, Combination
Fetus / drug effects*
Gestational Age
Heart Rate, Fetal / drug effects
Idarubicin / administration & dosage,  adverse effects*
Leukemia, Myeloid, Acute / drug therapy*
Placenta / drug effects,  pathology
Pregnancy Complications, Neoplastic / drug therapy*
Shock, Septic / chemically induced
Treatment Outcome
Reg. No./Substance:
0/Antibiotics, Antineoplastic; 58957-92-9/Idarubicin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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