Document Detail


Ictal and interictal high frequency oscillations in patients with focal epilepsy.
MedLine Citation:
PMID:  21030302     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: High frequency oscillations (HFOs) can be recorded with depth electrodes in focal epilepsy patients. They occur during seizures and interictally and seem important in seizure genesis. We investigated whether interictal and ictal HFOs occur in the same regions and how they relate to epileptiform spikes.
METHODS: In 25 patients, spikes, ripples (80-250 Hz) and fast ripples (FR: 250-500 Hz) and their co-occurrences were marked during interictal slow wave sleep (5-10 min), during 10 pre-ictal seconds and 5s following seizure onset. We compared occurrence and spatial distribution between these periods.
RESULTS: HFOs and spikes increased from interictal to ictal periods: the percentage of time occupied by ripples increased from 2.3% to 6.5%, FR from 0.2% to 0.8%, spikes from 1.1% to 4.8%. HFOs increased from interictal to pre-ictal periods in contrast to spikes. Spikes were in different channels in the interictal, pre-ictal and ictal periods whereas HFOs largely remained in the same channels.
CONCLUSIONS: HFOs remain confined to the same, possibly epileptogenic, area, during interictal and ictal periods, while spikes are more widespread during seizures than interictally.
SIGNIFICANCE: Ictal and interictal HFOs represent the same (epileptogenic) area and are probably similar phenomena.
Authors:
Maeike Zijlmans; Julia Jacobs; Yusuf U Kahn; Rina Zelmann; François Dubeau; Jean Gotman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-27
Journal Detail:
Title:  Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology     Volume:  122     ISSN:  1872-8952     ISO Abbreviation:  Clin Neurophysiol     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-09     Completed Date:  2011-05-17     Revised Date:  2013-09-17    
Medline Journal Info:
Nlm Unique ID:  100883319     Medline TA:  Clin Neurophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  664-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Montreal Neurological Institute and Hospital, McGill University, Montreal (Québec), Canada. g.j.m.zijlmans@umcutrecht.nl
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MeSH Terms
Descriptor/Qualifier:
Adult
Artifacts
Data Interpretation, Statistical
Electroencephalography*
Epilepsies, Partial / physiopathology*
Female
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Seizures / physiopathology*
Sleep / physiology
Software
Young Adult
Grant Support
ID/Acronym/Agency:
102710-1//Canadian Institutes of Health Research; MOP-10189//Canadian Institutes of Health Research
Comments/Corrections

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