| Ictal and interictal high frequency oscillations in patients with focal epilepsy. | |
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MedLine Citation:
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PMID: 21030302 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: High frequency oscillations (HFOs) can be recorded with depth electrodes in focal epilepsy patients. They occur during seizures and interictally and seem important in seizure genesis. We investigated whether interictal and ictal HFOs occur in the same regions and how they relate to epileptiform spikes. METHODS: In 25 patients, spikes, ripples (80-250Hz) and fast ripples (FR: 250-500Hz) and their co-occurrences were marked during interictal slow wave sleep (5-10min), during 10 pre-ictal seconds and 5s following seizure onset. We compared occurrence and spatial distribution between these periods. RESULTS: HFOs and spikes increased from interictal to ictal periods: the percentage of time occupied by ripples increased from 2.3% to 6.5%, FR from 0.2% to 0.8%, spikes from 1.1% to 4.8%. HFOs increased from interictal to pre-ictal periods in contrast to spikes. Spikes were in different channels in the interictal, pre-ictal and ictal periods whereas HFOs largely remained in the same channels. CONCLUSIONS: HFOs remain confined to the same, possibly epileptogenic, area, during interictal and ictal periods, while spikes are more widespread during seizures than interictally. SIGNIFICANCE: Ictal and interictal HFOs represent the same (epileptogenic) area and are probably similar phenomena. |
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Authors:
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Maeike Zijlmans; Julia Jacobs; Yusuf U Kahn; Rina Zelmann; François Dubeau; Jean Gotman |
Publication Detail:
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Type: Journal Article Date: 2010-10-27 |
Journal Detail:
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Title: Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology Volume: 122 ISSN: 1872-8952 ISO Abbreviation: Clin Neurophysiol Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883319 Medline TA: Clin Neurophysiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 664-71 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Montreal Neurological Institute and Hospital, McGill University, Montreal (Québec), Canada; University Medical Center Utrecht, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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