Document Detail


Ictal asystole: a benign condition?
MedLine Citation:
PMID:  17900291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ictal asystole (IA) has been implicated as a preventable cause of sudden unexplained death in epilepsy presumably provoked by a direct autonomic effect of the electrical stimulus on the heart. An electronic database search of patients with IA was performed comparing heart rate (HR) characteristics to a group of patients with vasovagal asystole. IA was seen in eight patients, all with temporal lobe epilepsy. No statistical difference was found in duration of asystole, bradycardia, and baseline HR characteristics except of a higher HR acceleration postasystole in the controls. None of the six patients with IA who underwent pacemaker implantation had recurrence of asystolic events during mean follow-up of 5 years. This study in a small group of patients suggests that the epileptic activation leading to IA is possibly mediated through a transient increase in vagal tone and not by a direct autonomic effect on the heart.
Authors:
Stephan U Schuele; Adriana C Bermeo; Eduardo Locatelli; Richard C Burgess; Hans O Lüders
Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2007-09-26
Journal Detail:
Title:  Epilepsia     Volume:  49     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-10     Completed Date:  2008-02-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  168-71     Citation Subset:  IM    
Affiliation:
Department of Neurology, Northwestern University, Chicago, IL, USA. s-schuele@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Bradycardia / diagnosis,  epidemiology,  prevention & control
Comorbidity
Databases as Topic / statistics & numerical data
Death, Sudden, Cardiac / epidemiology
Electrocardiography / methods,  statistics & numerical data*
Electroencephalography / statistics & numerical data
Epilepsy / diagnosis*,  epidemiology
Follow-Up Studies
Heart Arrest / diagnosis*,  epidemiology,  prevention & control
Heart Rate / physiology
Humans
Male
Middle Aged
Pacemaker, Artificial
Prognosis
Recurrence / prevention & control
Syncope, Vasovagal / diagnosis,  epidemiology,  prevention & control

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