Document Detail


Ictal SPECT using an attachable automated injector: clinical usefulness in the prediction of ictal onset zone.
MedLine Citation:
PMID:  19922314     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Ictal single-photon emission computed tomography (SPECT) is a valuable method for localizing the ictal onset zone in the presurgical evaluation of patients with intractable epilepsy. Conventional methods used to localize the ictal onset zone have problems with time lag from seizure onset to injection. PURPOSE: To evaluate the clinical usefulness of a method that we developed, which involves an attachable automated injector (AAI), in reducing time lag and improving the ability to localize the zone of seizure onset. MATERIAL AND METHODS: Patients admitted to the epilepsy monitoring unit (EMU) between January 1, 2003, and June 30, 2008, were included. The definition of ictal onset zone was made by comprehensive review of medical records, magnetic resonance imaging (MRI), data from video electroencephalography (EEG) monitoring, and invasive EEG monitoring if available. We comprehensively evaluated the time lag to injection and the image patterns of ictal SPECT using traditional visual analysis, statistical parametric mapping-assisted, and subtraction ictal SPECT coregistered to an MRI-assisted means of analysis. Image patterns were classified as localizing, lateralizing, and nonlateralizing. The whole number of patients was 99: 48 in the conventional group and 51 in the AAI group. RESULTS: The mean (SD) delay time to injection from seizure onset was 12.4+/-12.0 s in the group injected by our AAI method and 40.4+/-26.3 s in the group injected by the conventional method (P=0.000). The mean delay time to injection from seizure detection was 3.2+/-2.5 s in the group injected by the AAI method and 21.4+/-9.7 s in the group injected by the conventional method (P=0.000). The AAI method was superior to the conventional method in localizing the area of seizure onset (36 out of 51 with AAI method vs. 21 out of 48 with conventional method, P=0.009), especially in non-temporal lobe epilepsy (non-TLE) patients (17 out of 27 with AAI method vs. 3 out of 13 with conventional method, P=0.041), and in lateralizing the seizure onset hemisphere (47 out of 51 with AAI method vs. 33 out of 48 with conventional method, P=0.004). CONCLUSION: The AAI method was superior to the conventional method in reducing the time lag of tracer injection and in localizing and lateralizing the ictal onset zone, especially in patients with non-TLE.
Authors:
Jung-Ju Lee; Sang Kun Lee; Jang Wuk Choi; Dong-Wook Kim; Kyung Il Park; Bom Sahn Kim; Hyejin Kang; Dong Soo Lee; Seo-Young Lee; Sung Hun Kim; Chun Kee Chung; Hyeon Woo Nam; Kwang Ki Kim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta radiologica (Stockholm, Sweden : 1987)     Volume:  50     ISSN:  1600-0455     ISO Abbreviation:  Acta Radiol     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-20     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706123     Medline TA:  Acta Radiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1160-8     Citation Subset:  IM    
Affiliation:
Department of Neurology, Eulji General Hospital, Eulji University College of Medicine, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Electroencephalography
Epilepsy / radionuclide imaging*
Female
Humans
Injections / instrumentation
Magnetic Resonance Imaging
Male
Middle Aged
Radiopharmaceuticals / administration & dosage*
Retrospective Studies
Technetium Tc 99m Exametazime / administration & dosage
Tomography, Emission-Computed, Single-Photon / methods*
Chemical
Reg. No./Substance:
0/Radiopharmaceuticals; 100504-35-6/Technetium Tc 99m Exametazime
Comments/Corrections
Comment In:
Acta Radiol. 2009 Dec;50(10):1094   [PMID:  19922303 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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