Document Detail

Ictal EEG changes with corpus callosum section.
MedLine Citation:
PMID:  8504788     Owner:  NLM     Status:  MEDLINE    
Corpus callosum section diminishes but does not completely abolish secondary bilaterally synchronous interictal EEG discharges, yet often causes cessation of generalized seizures. The effects of corpus callosum section on ictal EEG patterns have not been described. We contrasted ictal EEG patterns before and after anterior callosotomy in 18 patients and before and after total callosotomy in 10 patients. Bilaterally synchronous seizure onset was disrupted in 5 of 11 anterior section patients and 5 of 5 total section patients. Seven of 18 anterior section patients and 5 of 10 total section patients had more localized seizure onset after the procedure; localization to the frontal lobe was observed after anterior or total section, but only total section patients had newly demonstrated posterior locations of seizure onset. These data suggest that the mechanisms by which bilaterally synchronous interictal and ictal discharges are generated differ. Although brainstem or diencephalic structures may contribute to formation of interictal bilateral synchrony, the corpus callosum may be the only pathway used in producing apparent bilateral synchronous seizure onset in patients with secondarily generalized seizures.
S S Spencer; A Katz; J Ebersole; E Novotny; R Mattson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  34     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:    1993 May-Jun
Date Detail:
Created Date:  1993-07-08     Completed Date:  1993-07-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  568-73     Citation Subset:  IM    
Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06510.
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MeSH Terms
Brain Stem / physiopathology
Corpus Callosum / physiopathology,  surgery*
Diencephalon / physiopathology
Epilepsies, Partial / diagnosis,  physiopathology,  surgery
Epilepsy, Frontal Lobe / physiopathology
Epilepsy, Generalized / diagnosis,  physiopathology,  surgery*
Follow-Up Studies
Functional Laterality / physiology
Neural Pathways / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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