Document Detail

Icodextrin: an alternative peritoneal dialysis fluid.
MedLine Citation:
PMID:  18950286     Owner:  NLM     Status:  MEDLINE    
Peritoneal dialysis is a home dialysis therapy in which a fluid known as dialysate is placed into the patient's peritoneal cavity. The standard dialysate consists of a concentrated dextrose solution. Icodextrin is a glucose polymer that can be substituted for dextrose with avoidance of some of the glucose-dependant effects. The efficacy and safety of this compound was evaluated and compared with the standard dialysate solutions. It seems to be well-tolerated overall and may offer benefits in select populations of patients with kidney failure. This seems to be especially relevant in patients with more permeable peritoneal membranes who are known as 'high-transporters'.
Darshika Chhabra; Kevin Nash
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Expert opinion on drug metabolism & toxicology     Volume:  4     ISSN:  1742-5255     ISO Abbreviation:  Expert Opin Drug Metab Toxicol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-27     Completed Date:  2009-01-30     Revised Date:  2009-11-16    
Medline Journal Info:
Nlm Unique ID:  101228422     Medline TA:  Expert Opin Drug Metab Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1455-64     Citation Subset:  IM    
Evanston Northwestern Healthcare, Feinberg School of Medicine, Division of Nephrology and Hypertension, Chicago, Illinois, Il 60201, Evanston, USA.
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MeSH Terms
Blood Glucose / metabolism
Dialysis Solutions / adverse effects,  pharmacokinetics,  therapeutic use*
Glucans / adverse effects,  pharmacokinetics,  therapeutic use*
Glucose / administration & dosage,  adverse effects,  pharmacokinetics,  therapeutic use*
Hemodialysis, Home*
Kidney Failure, Chronic / drug therapy
Lipid Metabolism / drug effects
Materials Testing
Peritoneal Dialysis*
Reg. No./Substance:
0/Blood Glucose; 0/Dialysis Solutions; 0/Glucans; 0/icodextrin; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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