Document Detail

Ichthyotoxic and anticarcinogenic effects of triterpenoids from Sandoricum koetjape bark.
MedLine Citation:
PMID:  12951486     Owner:  NLM     Status:  MEDLINE    
After bioassay-guided fractionation of the extract from Sandoricum koetjape bark, which exhibited significant toxicity to killifish (Oryzias latipes), two ichthyotoxic triterpenoids were isolated and characterized as koetjapic acid and 3-oxo-olean-12-en-29-oic acid. These constituents, along with non-toxic katonic acid, had a remarkable inhibitory effect on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol 13-acetate (TPA), which is a preliminary in vitro screening method for possible anti-tumor-promoting agents. Of the triterpenoids active in vitro, koetjapic acid appears to be a promising cancer chemopreventive agent, since it significantly delayed tumor promotion in two-stage mouse skin carcinogenesis induced by 7,12-dimethylbenz(a)anthracene and promoted by TPA.
Intan Safinar Ismail; Hideyuki Ito; Teruo Mukainaka; Hiroshi Higashihara; Fumio Enjo; Harukuni Tokuda; Hoyoku Nishino; Takashi Yoshida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biological & pharmaceutical bulletin     Volume:  26     ISSN:  0918-6158     ISO Abbreviation:  Biol. Pharm. Bull.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-02     Completed Date:  2004-04-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9311984     Medline TA:  Biol Pharm Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1351-3     Citation Subset:  IM    
Faculty of Pharmaceutical Sciences, Okayama University, Okayama, Japan.
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MeSH Terms
9,10-Dimethyl-1,2-benzanthracene / antagonists & inhibitors,  toxicity
Anticarcinogenic Agents*
Carcinogens / antagonists & inhibitors,  toxicity
Epstein-Barr Virus Nuclear Antigens / drug effects
Fundulidae / physiology*
Meliaceae / chemistry*
Mice, Inbred ICR
Plant Bark / chemistry
Plant Extracts / chemistry,  pharmacology
Tetradecanoylphorbol Acetate / antagonists & inhibitors,  toxicity
Triterpenes / isolation & purification,  pharmacology*,  toxicity*
Reg. No./Substance:
0/Anticarcinogenic Agents; 0/Carcinogens; 0/Epstein-Barr Virus Nuclear Antigens; 0/Plant Extracts; 0/Triterpenes; 16561-29-8/Tetradecanoylphorbol Acetate; 57-97-6/9,10-Dimethyl-1,2-benzanthracene

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