Document Detail


Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy.
MedLine Citation:
PMID:  21031624     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Essential therapeutic drugs for Alzheimer's disease (AD) have not been developed. Since the neuritic atrophy leading to synaptic losses is one of the critical causes of memory impairment in AD, the effects of several constituents in tonic herbal medicines on neuritic atrophy and memory deficits have been studied. The present study investigated the effects of icariin, a main constituent in Epimedii Herba, a well known tonic crude drug, in an in vitro AD model and transgenic mouse AD model (5xFAD). Amyloid β(1-42)-induced atrophies of axons and dendrites were restored by post-treatment with icariin in rat cortical neurons. Administration of icariin for 8 days (p.o.) improved spatial memory impairment in 5xFAD mice. These novel findings suggest that icariin may improve memory dysfunction in AD and have a potential to extend neurites even when amyloid β-induced neurite atrophy has already occurred.
Authors:
Takuya Urano; Chihiro Tohda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytotherapy research : PTR     Volume:  24     ISSN:  1099-1573     ISO Abbreviation:  Phytother Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2011-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904486     Medline TA:  Phytother Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1658-63     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 John Wiley & Sons, Ltd.
Affiliation:
Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930-0194, Japan.
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / drug therapy*,  pathology
Amyloid beta-Peptides / adverse effects
Animals
Atrophy
Cells, Cultured
Disease Models, Animal
Drugs, Chinese Herbal / therapeutic use*
Flavonoids / therapeutic use*
Memory Disorders / drug therapy*
Mice
Mice, Transgenic
Neurites / drug effects,  pathology*
Peptide Fragments / adverse effects
Rats
Rats, Sprague-Dawley
Chemical
Reg. No./Substance:
0/Amyloid beta-Peptides; 0/Drugs, Chinese Herbal; 0/Flavonoids; 0/Peptide Fragments; 0/amyloid beta-protein (1-42); 489-32-7/icariin

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