| Icariin ameliorates streptozotocin-induced diabetic retinopathy in vitro and in vivo. | |
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MedLine Citation:
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PMID: 22312291 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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This study investigated the effect of Icariin (ICA) supplementation on diabetic retinopathy (DR) in a streptozotocin-induced diabetic rat model system. Fifty Sprague Dawley rats were randomly distributed into a control group and a streptozotocin-induced diabetes group. Diabetic rats were randomly divided into two groups; one group received ICA 5 mg/kg/day for 12 weeks by oral gavage; the other group received saline gavage as a placebo. Retinal morphological changes, endothelial markers (RECA), collagen IV (Col-IV), vascular endothelial growth factor (VEGF), and neuropathic changes (Thy-1 and Brn3a expression) of the retinal ganglion cells (RGCs) were investigated. The effects of ICA at various concentrations (0, 10(1), 10(2), 10(3) nmol/mL) on neurite growth were investigated also in retinal ganglion cells (RGC) cultured from both diabetic and normal animals. Numerous pathological changes (deceased expression of RECA, VEGF, Thy-1, and Brn3a as well as decreased Collagen IV and Müller cell content) were noted in the retinal vessels of diabetic rats; these changes were attenuated in diabetic animals that received ICA. ICA enhanced neurite growth in RGC from both normal rats and diabetic rats in a dose dependent fashion. ICA may be useful in the treatment of diabetic retinopathy. Further investigations are indicated. |
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Authors:
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Hua Xin; Feng Zhou; Tao Liu; Guang-Yong Li; Jing Liu; Zhe-Zhu Gao; Guang-Yi Bai; Hong Lu; Zhong-Cheng Xin |
Publication Detail:
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Type: Journal Article Date: 2012-01-16 |
Journal Detail:
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Title: International journal of molecular sciences Volume: 13 ISSN: 1422-0067 ISO Abbreviation: Int J Mol Sci Publication Date: 2012 |
Date Detail:
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Created Date: 2012-02-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101092791 Medline TA: Int J Mol Sci Country: Switzerland |
Other Details:
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Languages: eng Pagination: 866-78 Citation Subset: - |
Affiliation:
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Department of Ophthalmology, Beijing ChaoYang Hospital, Capital Medical University, Beijing 100043, China; E-Mail: xinly520@hotmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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